Calcium-Channel Blockade blunts the Renal Effects of Acute Nitric Oxide Synthase Inhibition in Healthy Humans.

CONCLUSION: Since MANI blunted L-NAME-induced renal hemodynamic changes, CCs participate in the renal responses to NOSI in healthy, sodium-replete humans, independent of changes in MAP and without apparent contribution of the AT1R. Because the rise in U8-iso-PGF2αV was essentially prevented during MANI+L-NAME, CC blockade may oppose the renal effects of NOSI in part by counteracting oxidative stress responses to acutely impaired renal NO bioavailability.
PMID: 28179255 [PubMed - as supplied by publisher]

Source: Am J Physiol Renal P... - February 7, 2017 Category: Urology & Nephrology Authors: Montanari A, Lazzeroni D, Pelà G, Crocamo A, Lytvyn Y, Musiari L, Cabassi A, Cherney DZ Tags: Am J Physiol Renal Physiol Source Type: research