Polyarthritis Caused by Meningococcal, Parvovirus Infections Polyarthritis Caused by Meningococcal, Parvovirus Infections
The authors present a case of primary meningococcal arthritis, a rare manifestation of meningococcal disease, often misdiagnosed. What was its unusual association with parvovirus B19 in this patient?Journal of Medical Case Reports
Conclusions: GCP patients (otherwise systemically healthy) were characterized by increased Th17-proinflammatory cell phenotype positive for the IL-23 receptor in peripheral blood. The proportion of Th17 cells that are negative for the IL-23 receptor in the peripheral blood of systemically healthy patients seemed to be unaffected by the presence or absence of chronic periodontitis.
Total saponin of Dioscorea collettii attenuates MSU crystal‑induced inflammation via inhibiting the activation of the NALP3 inflammasome and caspase‑1 in THP‑1 macrophages. Mol Med Rep. 2020 Mar 20;: Authors: Wang L, Zhu L, Duan C, Li L, Chen G Abstract Total saponins extracted from Dioscorea collettii (TSD), extracts of the Chinese herb Dioscorea, are thought to exhibit therapeutic benefit in gouty arthritis. However, its exact mechanism remains unclear. The current study aimed to elucidate the underlying mechanisms by investigating the effects of TSD on the inflammation induced by mon...
Publication date: Available online 2 April 2020Source: Life SciencesAuthor(s): Emerson Souza da Rocha, Fabiana de Campos Gomes, Murilo Romano de Oliveira, Ricardo Vinicius Bruneto, Rodrigo Miranda Ramos Borges, Enzo Prandi de Carvalho, Euradir Vitório Angeli-Junior, Glayber Falcão Garcia-Filho, João Pedro Lot Doná, Rodrigo Piloto de Oliveira Batanero, Carla Patrícia Carlos, João Simão de Melo-Neto
(BRONX, NY)—April 3, 2020—Montefiore Health System andAlbert Einstein College of Medicine has started treating very sick COVID-19 patients as part of a multicenter trial evaluating a potential therapy for the new disease. The double-blind, placebo-controlled trial is testing whether sarilumab, a drug already approved for treating rheumatoid arthritis, can halt the inflammation that can overwhelm the lungs of COVID-19 patients. A very similar drug yielded promising results in a recent study involving patients in China.
Condition: Rheumatoid Arthritis Interventions: Drug: SHR0302; Drug: Placebo Sponsor: Jiangsu HengRui Medicine Co., Ltd. Not yet recruiting
Condition: Arthritis, Rheumatoid Interventions: Biological: GSK3196165; Drug: csDMARD(s) Sponsors: GlaxoSmithKline; Iqvia Pty Ltd Not yet recruiting
Conditions: Chronic Inflammatory Disease; Angioedema; Severe Asthma; Lupus; Atopic Dermatitis; Psoriatic Arthritis; Multiple Sclerosis; Systemic Sclerosis Interventions: Genetic: Biobanking with genetic analysis; Other: SF-12 questionnaire Sponsors: University Hospital, Lille; FHU IMMINeNT Not yet recruiting
Authors: Köklü H, Üstün H, Köklü S PMID: 32233283 [PubMed - in process]
This study examined weight reduction as well as smoking as potential modifiable risk factors for PsA.The British Journal of Dermatology
Publication date: Available online 1 April 2020Source: Journal of Ayurveda and Integrative MedicineAuthor(s): Sanjeev Rastogi