Human cytomegalovirus detection in gastric cancer and its possible association with lymphatic metastasis

Increasing evidence suggests that human cytomegalovirus (HCMV) is associated with many human malignancies. However, its prevalence in gastric cancer (GC) and clinical association remain unknown. HCMV IgG and IgM antibodies in the sera of 80 GC patients and 80 healthy controls were detected using a microparticle enzyme immunoassay. The prevalence of HCMV UL47, UL55, UL56, and UL77 genes among 102 GC tumor tissues and adjacent normal specimens was measured by polymerase chain reaction (PCR) or nested PCR.

Source: Diagnostic Microbiology and Infectious Disease - February 7, 2017 Category: Microbiology Authors: Liang Zhang, Gangqiang Guo, Jianfeng Xu, Xiangwei Sun, Wenjing Chen, Jinji Jin, Changyuan Hu, Peichen Zhang, Xian Shen, Xiangyang Xue Source Type: research