Imidazoline 1 receptor activation preserves respiratory drive in spontaneously breathing newborn rats during dexmedetomidine administration

ConclusionsOur results suggest that in newborn rats undergoing dexmedetomidine sedation, the α2‐adrenoceptor, but not I1 receptor, is involved in the regulation of HR and respiratory frequency, and that activation of the I1 receptor plays a major role in the maintenance of respiratory drive.

Source: Pediatric Anesthesia - January 31, 2017 Category: Anesthesiology Authors: Nana Sato, Chikako Saiki, Junko Tamiya, Toshio Imai, Katsuhisa Sunada Tags: Research Report Source Type: research