A teach approach: visual mapping of chromosome translocation.

A teach approach: visual mapping of chromosome translocation. Med Educ Online. 2016 Jan;21(1):30816 Authors: Han P PMID: 28165954 [PubMed - in process]
Source: Medical Education Online - Category: Universities & Medical Training Tags: Med Educ Online Source Type: research

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Abstract In mammals, DNA methyltransferases transfer a methyl group from S-adenosylmethionine to the 5 position of cytosine in DNA. The product of this reaction, 5-methylcytosine (5mC), has many roles, particularly in suppressing transposable and repeat elements in DNA. Moreover, in many cellular systems, cell lineage specification is accompanied by DNA demethylation at the promoters of genes expressed at high levels in the differentiated cells. However, since direct cleavage of the C-C bond connecting the methyl group to the 5 position of cytosine is thermodynamically disfavoured, the question of whether DNA meth...
Source: Journal of Biosciences - Category: Biomedical Science Authors: Tags: J Biosci Source Type: research
MM is a clonal disorder of malignant plasma cells. Standard of care for newly diagnosed MM is induction with triplet regimen chemotherapy followed by ASCT. Patients are stratified based on cytogenetic analysis as being high risk and standard risk. t(11;14) comprises ∼ 15-20% of newly diagnosed MM, making it the most common translocation. t(11;14) has been classified as standard risk. However, it is now increasingly being considered as intermediate risk, conferring inferior outcome compared with standard-risk MM.(Walker, Wardell et al.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 358 Source Type: research
In conclusion, approaches utilized in the current study are highly suited to characterize the genetic constitution of PAs. PMID: 31966040 [PubMed]
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Conclusion: Taken together, our findings suggest patriscabrin F may exhibit anti-inflammatory properties via the inhibition of NF-κB, AP-1, IRF3, and JAK-STAT activation in LPS-induced macrophages.Graphical abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
Authors: Grevel A, Becker T Abstract Mitochondria import the vast majority of their proteins via dedicated protein machineries. The translocase of the outer membrane (TOM complex) forms the main entry site for precursor proteins that are produced on cytosolic ribosomes. Subsequently, different protein sorting machineries transfer the incoming preproteins to the mitochondrial outer and inner membrane, the intermembrane space and the matrix. In this review, we highlight the recently discovered role of porin, also termed voltage-dependent anion channel (VDAC), in mitochondrial protein biogenesis. Porin forms the major...
Source: Biological Chemistry - Category: Chemistry Tags: Biol Chem Source Type: research
Conclusion:In summary, the hexamer and trimer of sTNFRII-adiponectin fusion protein had both TNFα-antagonizing and glucose uptake-promoting activities, although neither could improve glucose uptake in the cell model of insulin resistance. PMID: 31965947 [PubMed - as supplied by publisher]
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
Publication date: Available online 21 January 2020Source: NeuronAuthor(s): Alexandra Mansell Kaufman, Tristan Geiller, Attila LosonczySummaryDuring spatial learning, hippocampal (HPC) place maps reorganize to represent new goal locations, but little is known about the circuit mechanisms facilitating these changes. Here, we examined how neuromodulation via locus coeruleus (LC) projections to HPC area CA1 (LC-CA1) regulates the overrepresentation of CA1 place cells near rewarded locations. Using two-photon calcium imaging, we monitored the activity of LC-CA1 fibers in the mouse dorsal HPC. We find that the LC-CA1 projection ...
Source: Neuron - Category: Neuroscience Source Type: research
Publication date: April 2020Source: Phytochemistry Letters, Volume 36Author(s): Lai-Bin Zhang, Hui-Hui Zhu, Li-Min Guo, Jie-Li LvAbstractArtemargyinolide E (AE), a new sesquiterpene lactone was isolated from the traditional Chinese medicine Artemisia argyi. Its structure was elucidated based on the extensive analysis of spectroscopic data. The absolute configuration of AE was assigned by X-ray crystallographic analysis. The effect of AE and its mechanism on lipopolysaccharide (LPS)-induced inflammatory responses in macrophages were investigated. AE displayed the inhibitory activity on the production of nitrogen oxide (NO) ...
Source: Phytochemistry Letters - Category: Chemistry Source Type: research
Authors: Wu J, Li YT, Tian XT, Liu YS, Wu ML, Li PN, Liu J Abstract BACKGROUNDS: Anaplastic thyroid cancer/ATC is highly lethal malignancy without reliable chemotherapeutic drug. Resveratrol possesses anti-ATC activities but encounters resistance in some cases due to certain unknown reason(s). OBJECTIVE: Because signal transducer and activator of transcription/STAT3 signaling is critical for ATC cell survival and the main molecular target of resveratrol, its roles in determining the fates of resveratrol-treated ATC cells were investigated here. METHODS: Human THJ-11T, THJ-16 and THJ-21T ATC cell lines were ...
Source: Cancer Biomarkers - Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research
The Journal of Physical Chemistry BDOI: 10.1021/acs.jpcb.9b09587
Source: Journal of Physical Chemistry B - Category: Chemistry Authors: Source Type: research
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