Pernicious anemia: Fundamental and practical aspects in diagnosis.

Pernicious anemia: Fundamental and practical aspects in diagnosis. Cardiovasc Hematol Agents Med Chem. 2017 Feb 03;: Authors: Tun AM, Thein KZ, Myint ZW, Oo TH Abstract Pernicious anemia (PA), the most common cause of cobalamin deficiency anemia worldwide, is an autoimmune disease of multifactorial etiologies involving complex environmental and immunological factors. Although it was first reported by Addison in 1849 with subsequent advances in understanding of pathogenesis and molecular biology, diagnosis of pernicious anemia is still challenging for clinicians because of its complexity and diverse clinical presentations. Herein, we provide an overview of PA, mainly focusing on its scientific and practical aspects in diagnosis. We also discuss the limitations of currently available diagnostic tools for evaluation of cobalamin deficiency and PA. PMID: 28164751 [PubMed - as supplied by publisher]
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research