NLRP3 (Nucleotide Oligomerization Domain-Like Receptor Family, Pyrin Domain Containing 3)-Caspase-1 Inflammasome Degrades Contractile Proteins: Implications for Aortic Biomechanical Dysfunction and Aneurysm and Dissection Formation.

CONCLUSIONS: Inflammasome-caspase-1-mediated degradation of SMC contractile proteins may contribute to aortic biomechanical dysfunction and AAD development. This cascade may be a therapeutic target in AAD formation. In addition, glyburide may have protective effects against AAD development. PMID: 28153878 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/28153878?dopt=Abstract

Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 1, 2017 Category: Cardiology Authors: Wu D, Ren P, Zheng Y, Zhang L, Xu G, Xie W, Lloyd EE, Zhang S, Zhang Q, Curci JA, Coselli JS, Milewicz DM, Shen YH, LeMaire SA Tags: Arterioscler Thromb Vasc Biol Source Type: research