Novel Mechanisms of Sodium Retention in Obesity: Phosphorylation of NKCC2 and Regulation of SPAK/OSR1 by AMPK.

In conclusion, this study identifies increased phosphorylation of NKCC2 on S126 as a hitherto unrecognized mediator of enhanced sodium reabsorption in obesity, and identifies a new role for AMPK in regulating the activity of SPAK/OSR1.
PMID: 24808538 [PubMed - as supplied by publisher]

Source: Am J Physiol Renal P... - May 7, 2014 Category: Urology & Nephrology Authors: Davies MR, Fraser SA, Galic S, Choy SW, Katerelos M, Gleich K, Kemp BE, Mount PF, Power DA Tags: Am J Physiol Renal Physiol Source Type: research