Systematic probing of the bacterial RNA structurome to reveal new functions.

Systematic probing of the bacterial RNA structurome to reveal new functions.
Curr Opin Microbiol. 2017 Feb 01;36:14-19
Authors: Ignatova Z, Narberhaus F
Abstract
RNA folds into intricate structures. Recent discoveries using next-generation sequencing (NGS) approaches have revealed unprecedented structural complexity with a pivotal role in regulating RNA function and stability. Here, we present new discoveries from the transcriptome-wide determination of RNA structuromes in bacteria and discuss emerging concepts in the role of mRNA structures in regulating transcription, translation and degradation. We also provide critical viewpoints on the use of NGS approaches for elucidating of RNA structuromes at the systems level.
PMID: 28160611 [PubMed - as supplied by publisher]

Source: Current Opinion in Microbiology - January 31, 2017 Category: Microbiology Authors: Ignatova Z, Narberhaus F Tags: Curr Opin Microbiol Source Type: research