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Researchers identify 'synthetic essentiality' as novel approach for locating cancer therapy targets

(University of Texas M. D. Anderson Cancer Center) A new method has been found for identifying therapeutic targets in cancers lacking specific key tumor suppressor genes. The process, which located a genetic site for the most common form of prostate cancer, has potential for developing precision therapy for other cancers, such as breast, brain and colorectal, say researchers at The University of Texas MD Anderson Cancer Center. Study results were published in the Feb. 6 online issue of Nature.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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In this study, we show that MeCP2 may play a critical role in the suppression of glioma progression. Stable overexpression of MeCP2in C6 glioma cells inhibits proliferation, migration, invasion, and adhesion. Moreover, MeCP2 overexpression inhibits pERKand BDNF expression while inducing GFAP expression in C6 glioma. These findings suggest that MeCP2 may play a crucial role in suppression of glioma progression. Graphical abstract
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
In conclusion, de novo metastasis is a major contributor to cancer mortality among patients with cancer in the USA.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: Original Research Source Type: research
In Westwood, more than 100 faculty experts from 25 departments have embarked on anall-encompassing push to cut the health and economic impacts of depression in half by the year 2050. The mammoth undertaking will rely on platforms developed by the new Institute for Precision Health, which will harness the power of big data and genomics to move toward individually tailored treatments and health-promotion strategies.On the same 419 acres of land, researchers across the spectrum, from the laboratory bench to the patient bedside, are ushering in a potentially game-changing approach to turning the body ’s immune defenses a...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
A multiphase, approximate biological effective dose (BEDA) equation was introduced because most treatment planning systems (TPS) are incapable of calculating the true BED (BEDT). This work investigates the accuracy and precision of the multiphase BEDA relative to the BEDT in clinical cases. Ten patients with head and neck cancer and 10 patients with prostate cancer were studied using their treatment plans from Pinnacle3 9.2 (Philips Medical, Fitchburg, WI). The organs at risk (OARs) that were studied are the normal brain, left and right optic nerves, optic chiasm, spinal cord, brainstem, bladder, and rectum.
Source: Medical Dosimetry - Category: Radiology Authors: Tags: Medical Physics Contribution: Source Type: research
Author Affiliations open 1 McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, Canada 2 Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain 3 Universitat Pompeu Fabra (UPF), Barcelona, Spain 4 CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain 5 School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Canada 6 Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA 7 Department of Economics, Brigham Young University, Provo, Utah, USA 8 Population Studies Division, Health Canada, Ottawa, Cana...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
We reviewed available evidence on coffee drinking and the risk of all cancers and selected cancers updated to May 2016. Coffee consumption is not associated with overall cancer risk. A meta-analysis reported a pooled relative risk (RR) for an increment of 1 cup of coffee/day of 1.00 [95% confidence interval (CI): 0.99–1.01] for all cancers. Coffee drinking is associated with a reduced risk of liver cancer. A meta-analysis of cohort studies found an RR for an increment of consumption of 1 cup/day of 0.85 (95% CI: 0.81–0.90) for liver cancer and a favorable effect on liver enzymes and cirrhosis. Ano...
Source: European Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Review Articles: Lifestyle Source Type: research
odríguez C Abstract In the last decades, the development of new technologies applied to lipidomics has revitalized the analysis of lipid profile alterations and the understanding of the underlying molecular mechanisms of lipid metabolism, together with their involvement in the occurrence of human disease. Of particular interest is the study of omega-3 and omega-6 long chain polyunsaturated fatty acids (LC-PUFAs), notably EPA (eicosapentaenoic acid, 20:5n-3), DHA (docosahexaenoic acid, 22:6n-3), and ARA (arachidonic acid, 20:4n-6), and their transformation into bioactive lipid mediators. In this sense, new f...
Source: Clinical Prostate Cancer - Category: Cancer & Oncology Authors: Tags: Clin Transl Med Source Type: research
In this study, we focused on two pathways of cardiomyocytes or heart cells: the Hippo pathway, which is involved in stopping renewal of adult cardiomyocytes, and the dystrophin glycoprotein complex (DGC) pathway, essential for cardiomyocyte normal functions." Previous work had hinted that components of the DGC pathway may somehow interact with members of the Hippo pathway. The researchers genetically engineered mice to lack genes involved in one or both pathways, and then determined the ability of the heart to repair an injury. These studies showed for the first time that dystroglycan 1, a component of the DGC ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusion: PSMA avid sites of disease detected on PET/CT in patients with prostate cancer followed the distribution of prostate cancer previously described in autopsy studies, and with similar detection rates. 68Ga-PSMA PET/CT is therefore an accurate noninvasive tool that should be included in recommendations of society guidelines in addition to abdomino-pelvic CT/MR and bone scintigraphy to evaluate the extent of disease in patients with prostate cancer. Research Support: Not Supported.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Prostate III: PSMA Imaging Source Type: research
More people die of lung cancer each year than breast, colon, and prostate cancers combined. One particularly lethal form of the disease is lung adenocarcinoma or LUAD, which afflicts both smokers and non-smokers. In many patients diagnosed with LUAD, tumors cells have already spread to the brain, leading to decreased quality of life and low survival rates. A Yale team of researchers conducted a study to determine how those tumor cells manage to grow outside the lungs.
Source: Yale Science and Health News - Category: Universities & Medical Training Tags: Yale News Source Type: news
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