Correlating bacterial shedding with fecal corticosterone levels and serological responses from layer hens experimentally infected with Salmonella Typhimurium

AbstractSalmonella Enteriditis andSalmonella Typhimurium are commonly isolated during egg-related outbreaks of salmonellosis and represent a significant international public health issue. In Australia,Salmonella Typhimurium is the most common serovar identified in egg product related foodborne outbreaks. While a number of studies have investigatedSalmonella shedding and host responses to infection, they have been conducted over a short time period. The present study sought to characterise bacterial shedding and host responses to infection in hens infected with onlySalmonella Typhimurium or co-infected with bothSalmonella Typhimurium andSalmonella Mbandaka over a 16  week period.Salmonella shedding was quantified using the most probable number and qPCR methods and was highly variable over the course of the experiment. On day 1, fecal corticosterone metabolites in birds infected withSalmonella Typhimurium (674.2  ± 109.3 pg/mg) were significantly higher than control (238.0 ± 12.62 pg/mg) or co-infected (175.4 ± 8.58 pg/mg) birds. The onset of lay occurred between weeks 6–8 post-infection (pi) and Fecal corticosterone metabolite (FCM) concentrations increased in both control and co-infected bir ds. Antibody responses to infection were monitored in both serum and yolk samples.Salmonella Typhimurium specific antibody was lower in co-infected animals than monoinfected animals. Bacterial loads in internal o...
Source: Veterinary Research - Category: Veterinary Research Source Type: research

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In this study, the underlying mechanism of nitrite on the susceptibility of tilapia leucocytes to Streptococcus agalactiae (S. agalactiae) was studied. We found that a high dose of heat-killed S. agalactiae decreased tilapia leucocytes cell viability, whereas nitrite decreased the cell viability of leucocytes exposed to a low dose of bacteria. Bacterial challenge increased the production of nitric oxide (NO), whereas nitrite and bacteria coexposure caused higher NO production than nitrite or bacterial exposure alone. Cell viability increased after elimination of NO, and negative correlations existed between cell viability ...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Publication date: Available online 13 December 2019Source: Chinese Chemical LettersAuthor(s): Li Jin, Xun Liu, Changhao Bian, Jie Sheng, Yishan Song, Yongheng ZhuAbstractTo develop a novel food preservation technology for efficiently enhance bactericidal activity in a long term, hollow mesoporous silica spheres (HMSS) with regular nanostructures were applied to encapsulate natural organic antimicrobial agents. The chemical structures, morphologies and thermal stabilities of linalool, HMSS and linalool-functionalized hollow mesoporous silica spheres (L-HMSS) nanoparticles were evaluated by polarimeter, field emission scanni...
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
CONCLUSIONS: Primary ocular toxoplasmosis presenting in adulthood is a relatively uncommon cause of posterior uveitis in New Zealand. This condition should be considered in any patient presenting with retinitis or optic nerve inflammation without a retinochoroidal scar. This disease tends to relapse; thus, close follow-up is required. PMID: 31833248 [PubMed - in process]
Source: Korean Journal of Ophthalmology : KJO - Category: Opthalmology Tags: Korean J Ophthalmol Source Type: research
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Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Bacterial-mediated cancer therapy (BMCT) has become a hot topic in the area of antitumor treatment. Salmonella has been recommended to specifically colonize and proliferate inside tumors and even inhibit tumor growth. Salmonella typhimurium (S. typhimurium) is one of the most promising mediators, which can be easily manipulated. S. typhimurium has been engineered and designed as cancer-targeting therapeutics, and can be improved by combining with other therapeutic methods, e.g. chemotherapy and radiotherapy, which regulate the tumor microenvironment synergistically. In view of all these strengths, the engineered attenuated...
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Conclusion: The rate of scabies recurrence among adult patients in Saudi Arabia was high, and is comparable with previous report in Japan. The study suggests that male gender, first tertile, and high humidity were independently associated with the high rate of scabies recurrences among adults. An interventional program to lower the rate of scabies recurrences and prevent outbreak should be undertaken. PMID: 31828279 [PubMed - in process]
Source: Saudi Medical Journal - Category: Middle East Health Tags: Saudi Med J Source Type: research
CONCLUSIONNeuroendocrine carcinomas of head and neck region are aggressive tumors with poor prognosis, low incidence and their diagnosis is not obvious. The treatment protocol depends on the type, the site of the lesions, and metastasis status. It’s still not well codified.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Abstract In 2018, a hepatitis A virus outbreak was identified among internally displaced persons in Syria. Sequence analysis based on the viral protein 1/2 junction revealed that the causative virus belonged to genotype IB. A high displacement rate, deteriorated sanitary and health conditions, and poor water quality likely contributed to this outbreak. PMID: 31829918 [PubMed - as supplied by publisher]
Source: Emerging Infectious Diseases - Category: Infectious Diseases Authors: Tags: Emerg Infect Dis Source Type: research
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Source: NYT Health - Category: Consumer Health News Authors: Tags: Medical Devices Bacteria Infections Recycling of Waste Materials Defective Products Surgery and Surgeons your-feed-health Boston Scientific Corporation Food and Drug Administration United States Source Type: news
Just days after health officials urged Americans to throw out their salad kits over E. coli concerns, the Food and Drug Administration announced it's investigating three separate E. coli outbreaks linked to salad products.
Source: - Health - Category: Consumer Health News Source Type: news
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