A Vector Based on the Chicken Hypersensitive Site 4 Insulator Element Replicates Episomally in Mammalian Cell.

In conclusion, apart from a few free vector forms, the cHS4-containing vector mainly replicates episomally in mammalian cells and out-performs comparable systems in terms of yielding both higher expression levels and stability levels. PMID: 28155604 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/28155604?dopt=Abstract

Source: Current Gene Therapy - February 1, 2017 Category: Genetics & Stem Cells Authors: Zhang X, Wang XY, Jia YL, Guo X, Wang YF, Wang TY Tags: Curr Gene Ther Source Type: research