Envisia reports positive interim results from Phase II trial of ENV515 in glaucoma

US-based clinical-stage biotechnology firm Envisia Therapeutics has reported positive interim results from the second cohort of the ENV515 (travoprost XR) Phase II trial to treat patients with glaucoma.
Source: Drug Development Technology - Category: Pharmaceuticals Source Type: news

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This study was designed to measure retinal perfusion density changes on optical coherence tomography (OCT) angiography and OCT thickness alterations associated with acutely increased IOP after intravitreal injections. Methods: Retrospective observational clinical study of 40 eyes (39 patients) with various retinopathies from October 2016 to June 2017 at a tertiary care retina clinic in NYC. Patients were older than 18 years, with vision>20/100, able to fixate and without media opacities precluding OCT angiography, receiving intravitreal bevacizumab or aflibercept for diabetic retinopathy, retinal vein occlusion, macu...
Source: RETINA - Category: Opthalmology Tags: Original Study Source Type: research
ZO-1 associates with α3 integrin and connexin43 in trabecular meshwork and Schlemm's canal cells. Int J Physiol Pathophysiol Pharmacol. 2020;12(1):1-10 Authors: Li X, Acott TS, Nagy JI, Kelley MJ Abstract Cellular structures that perform essential homeostatic functions include tight junctions, gap junctions, desmosomes and adherens junctions. The aqueous humor, produced by the ciliary body, passes into the anterior chamber of the eye and is filtered by the trabecular meshwork (TM), a tiny tissue found in the angle of the eye. This tissue, along with Schlemm's canal (SC) inner wall cells, is thoug...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research
Condition:   Primary Glaucoma Intervention:   Device: eyeWatch Sponsors:   dr. Kaweh Mansouri;   Manchester Royal Eye Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionsBetter counselling of, and communication with, the patient would help increase their awareness regarding their condition and the care required. This has the potential to enable better compliance with and adherence to treatment. Standardized training of ophthalmologists to improve clinical diagnosis of glaucoma would also go a long way.
Source: International Ophthalmology - Category: Opthalmology Source Type: research
Publication date: Available online 25 March 2020Source: Nitric OxideAuthor(s): Yuan Lei, Yanting Gao, Maomao Song, Wenjun Cao, Xinghuai Sun
Source: Nitric Oxide - Category: Chemistry Source Type: research
To determine the change in global and regional Humphrey visual field (VF) after glaucoma drainage device (GDD) implantation over 3-year follow-up.
Source: American Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Original Articles Source Type: research
The transient receptor potential vanilloid member 1 (TRPV1) in the central nervous system may contribute to homeostatic plasticity by regulating intracellular Ca2+, which becomes unbalanced in age-related neurodegenerative diseases, including Alzheimer’s and Huntington’s. Glaucomatous optic neuropathy – the world’s leading cause of irreversible blindness – involves progressive degeneration of retinal ganglion cell (RGC) axons in the optic nerve through sensitivity to stress related to intraocular pressure (IOP). In models of glaucoma, genetic deletion of TRPV1 (Trpv1–/–) accelerate...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Conditions:   Glaucoma;   Glaucoma, Primary Open Angle Intervention:   Procedure: ultrasound cyclo plasty Sponsor:   Zhongshan Ophthalmic Center, Sun Yat-sen University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
PURPOSE: To investigate the association between balance and gait measures with fall rates in glaucoma patients. METHODS: Balance and gait were measured for 239 participants with glaucoma or suspected glaucoma. Daily falls were evaluated over 24 mon...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Progressive glaucoma despite low or normal IOP levels can be challenging to manage. What are the best ways to approach this condition?Current Opinion in Ophthalmology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Ophthalmology Journal Article Source Type: news
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