Long- but not short-term estradiol treatment induces renal damage in midlife ovariectomized Long-Evans rats.

In conclusion, long-term E2 lowered blood pressure but exerted detrimental effects on kidney health in midlife OVX Long-Evans rats, whereas short-term E2 lowered blood pressure and reduced renal damage. These findings highlight that the duration of hormone therapy may be an important factor for renal health in aging postmenopausal women. PMID: 28153915 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/28153915?dopt=Abstract

Source: Am J Physiol Renal P... - January 31, 2017 Category: Urology & Nephrology Authors: Zimmerman MA, Hutson DD, Trimmer EH, Kashyap SN, Duong JL, Murphy B, Grissom EM, Daniel JM, Lindsey SH Tags: Am J Physiol Renal Physiol Source Type: research