Impairment in the mesohippocampal dopamine circuit following exposure to the brominated flame retardant, HBCDD

Publication date: Available online 4 February 2017 Source:Environmental Toxicology and Pharmacology Author(s): Camille Pham-Lake, Elizabeth B. Aronoff, Chad R. Camp, Aimee Vester, Sam J. Peters, W.Michael Caudle Many chemicals have been used to increase the safety of consumer products by reducing their flammability and risk for ignition. Recent focus on brominated flame retardants, such as polybrominated diphenyl ethers (PBDEs) has shown them to contribute to neurobehavioral deficits in children, including learning and memory. As the manufacture and use of PBDEs has been reduced, replacement chemicals, such as hexabromocyclododecane (HBCDD) have been substituted. Our current study evaluated the neurotoxicity of HBCDD, concentrating on dopaminergic innervation to the hippocampus. Using an in vivo model, we exposed male mice to HBCDD and then assessed alterations to the dopamine synapse 6 weeks later. These exposures elicited significant reductions in presynaptic dopaminergic proteins, including TH, COMT, MAO-B, DAT, VMAT2, and alpha-synuclein. In contrast, postsynaptic dopamine receptors were not impaired. These findings suggest that the mesohippocampal dopamine circuit is vulnerable to HBCDD and the dopamine terminal may be a selective target for alteration.

Source: Environmental Toxicology and Pharmacology - February 4, 2017 Category: Environmental Health Source Type: research