Acinetodin and Klebsidin, RNA Polymerase Targeting Lasso Peptides Produced by Human Isolates of Acinetobacter gyllenbergii and Klebsiella pneumoniae

ACS Chemical BiologyDOI: 10.1021/acschembio.6b01154
Source: ACS Chemical Biology - Category: Chemistry Authors: Source Type: research

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Publication date: Available online 17 September 2019Source: American Journal of Infection ControlAuthor(s): Sun-young Kim, Sung-il Cho, Ji Hwan BangWe studied bloodstream infection by multidrug-resistant Acinetobacter baumannii among patients in a medical intensive care unit. Over a 7-year period, 47 of 441 colonized patients developed a bloodstream infection.. Endotracheal intubation (odds ratio [OR], 5.88), ventilator support (OR, 3.70), and central venous catheterization (OR, 3.48) were identified as risk factors.
Source: American Journal of Infection Control - Category: Infectious Diseases Source Type: research
CONCLUSION: Certain decontamination protocols and regulations must be defined to eliminate bacteria and fungi, as both were present in samples from all of the laboratories. PMID: 31522164 [PubMed - in process]
Source: Journal of the International Academy of Periodontology - Category: Dentistry Tags: J Int Acad Periodontol Source Type: research
TnaphA6-carrying repAci6 plasmids have been detected in Acinetobacter baumannii isolates belonging to global clones, GC1 and GC2, worldwide. Here, we examined whether RepAci6 plasmids family play a role in the di...
Source: BMC Microbiology - Category: Microbiology Authors: Tags: Research article Source Type: research
While the antibiotic era has come and gone, antimicrobial peptides (AMPs) hold promise as novel therapies to treat multidrug resistant (MDR) pathogens in an age where the threat of multidrug resistance escalates worldwide. Here, we report the bactericidal properties of NuriPep 1653, a novel 22 mer and non-modified peptide. NuriPep 1653 was identified within the sequence of the non-antimicrobial P54 protein, which is involved in nutrient reservoir activity in Pisum sativum. Total bacterial clearance of Acinetobacter baumannii cells (1 × 108 cells/mL) was observed using only 4 × MIC (48 μg/mL) of NuriPep 1653 ...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Acinetobacter calcoaceticus-Acinetobacter baumannii complex is considered one of the main causes of hospital-acquired infections. Acinetobacter seifertii was recently characterized within this complex and it has been described as an emergent pathogen associated with bacteremia. The emergence of multidrug-resistant (MDR) bacteria, including Acinetobacter sp., is considered a global public health threat and an environmental problem because MDR bacteria have been spreading from several sources. Therefore, this study aimed to characterize an environmental MDR A. seifertii isolate (SAb133) using whole genome sequencing and a co...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
In this study, we evaluated the microbiota of perilla leaves harvested in South Korea using Illumina MiSeq sequencing of the 16S rRNA gene. In total, 2,743,003 sequencing reads were obtained, and 92–437 operational taxonomic units were observed in all samples. Bacterial loads were quantified, and the diversity indices were compared. Differences in the microbiota among sampling times and regions were also investigated. Proteobacteria and Firmicutes were predominant phyla at both times. At the class level, the bacterial communities were composed primarily of Alphaproteobacteria, Bacilli, and Gammaproteobacteria. Divers...
Source: Food Research International - Category: Food Science Source Type: research
ConclusionThe prevalence of MDR-GNB in Iranian burn patients is very high. Thus, a comprehensive infectious control programme, a reduction in the use of antibiotic prophylaxis, and thorough information regarding antimicrobial resistance patterns is required.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Source: Infection and Drug Resistance - Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
Authors: Dafopoulou K, Vourli S, Tsakris A, Pournaras S Abstract Introduction: Carbapenem-resistant Acinetobacter baumannii (CRAB) currently comprise>50% of A. baumannii isolates in Europe and the USA and commonly are extensively- or pandrug-resistant. They cause severe hospital infections, which according to CDC have very high mortality. Polymyxins are universally recognized as the last-line choice against CRAB infections. The role of polymyxin susceptibility testing (ST) for these pathogens remains subject of debate although it is critical for selection of appropriate antimicrobial therapy. There are significa...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
Abstract Phosphopantetheine adenylyl transferase catalyzes a rate limiting penultimate step of the multistep reaction which produces coenzyme A (CoA) as a final product. CoA is required as an essential cofactor in a number of metabolic reactions. Therefore inhibiting the function of this enzyme will lead to cell death in bacteria. Acinetobacter baumannii is multi drug resistant pathogen and causes infections in immunocompromised patients. AbPPAT has been cloned, expressed, purified and crystallized and structures of two complexes of AbPPAT with dephospho coenzyme A (dPCoA) and coenzyme A (CoA) have been determined...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Tags: Int J Biol Macromol Source Type: research
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