Lupus (Systemic Lupus Erythematosus)

Title: Lupus (Systemic Lupus Erythematosus)Category: Diseases and ConditionsCreated: 8/20/2013 2:45:00 PMLast Editorial Review: 5/8/2014 12:00:00 AM
Source: MedicineNet Arthritis General - Category: Rheumatology Source Type: news

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This study is registered with ClinicalTrials.gov, number NCT02708095.FindingsBetween March 24, 2016, and April 27, 2017, 314 patients were randomly assigned to receive placebo (n=105), baricitinib 2 mg (n=105), or baricitinib 4 mg (n=104). At week 24, resolution of SLEDAI-2K arthritis or rash was achieved by 70 (67%) of 104 patients receiving baricitinib 4 mg (odds ratio [OR] vs placebo 1·8, 95% CI 1·0–3·3; p=0·0414) and 61 (58%) of 105 patients receiving baricitinib 2 mg (OR 1·3, 0·7–2·3; p=0·39). Adverse events were reported in 68 (65%) patients in the p...
Source: The Lancet - Category: General Medicine Source Type: research
Arthritis&Rheumatology, EarlyView.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Source Type: research
A new Antimicrobial Resistance (AMR) Accelerator Programme is part of new Calls for proposals launched today by the Innovative Medicines Initiative (IMI). Of the other topics launched in the Calls, many address brain disorders (e.g. Alzheimer's disease, Parkinson's disease, Huntington's disease, major depression) and immune-mediated diseases (e.g. rheumatoid arthritis and lupus as well as inflammatory bowel diseases such as Crohn's and colitis, and skin diseases like dermatitis and psoriasis).
Source: eHealth News EU - Category: Information Technology Tags: Featured Open Calls Source Type: news
Publication date: Available online 17 July 2018Source: Autoimmunity ReviewsAuthor(s): Aram Musaelyan, Sergey Lapin, Vladimir Nazarov, Olga Tkachenko, Boris Gilburd, Alexandra Mazing, Lilia Mikhailova, Yehuda ShoenfeldAbstractVimentin is a protein of intermediate filament family, which is expressed in all mesenchymal cells. Vimentin plays a key role in the physiology of the cell, cellular interactions and the functioning of the immune system. Post-translationally modified and native forms of vimentin are involved in the pathogenesis of inflammation and many autoimmune diseases: rheumatoid arthritis, sarcoidosis, systemic lu...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
The prevalence and relevance of traditional cardiovascular risk factors in primary Sjögren's syndrome. Clin Exp Rheumatol. 2018 May 30; Authors: Bartoloni E, Alunno A, Valentini V, Valentini E, La Paglia GMC, Leone MC, Cafaro G, Marcucci E, Bonifacio AF, Luccioli F, Gerli R Abstract Accelerated atherosclerosis is a distinct feature of some inflammatory and autoimmune disorders and several specific autoimmune mechanisms and persistent inflammation have been identified to exert a pivotal role in precocious atherosclerotic damage in these disorders. Although increased atherosclerotic risk has been we...
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
A new study has raised the possibility that stress may cause autoimmune disease, such as lupus or rheumatoid arthritis, because it found a higher incidence of autoimmune diseases among people who were previously diagnosed with stress-related disorders. I have patients who heard about this research and are saying, “I knew it!” But before we accept a potential link between stress and autoimmune disease, let’s look at some details of the study and consider how we define the terms “autoimmune disease,” “stress,” and “stress-related disorder.” What is autoimmune disease? The...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Autoimmune diseases Health Stress Source Type: blogs
ConclusionBecause 28% of our patients with longstanding and strictly defined PAPS could be mistakenly classified as SLE, they were at risk of deleterious therapeutic management. We therefore suggest that any future classification for SLE should specifically require at least one SLE-specific criterion for patients with aPL.
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
Publication date: February 2018Source: Journal of Applied Biomedicine, Volume 16, Issue 1Author(s): Lucia Lauková, Barbora Kone─ŹnáAbstractNeutrophils play an important role as the central mediators of the innate immune defence response, providing the first line of host protection. It was shown that these cells can trap and kill various microorganisms through different ways. One of them is a release of neutrophil extracellular traps (NETs) composed of chromatin fibrils and antimicrobial proteins. There is the evidence that the release of NETs does not have only a beneficial effect. NETs can trap and kill micr...
Source: Journal of Applied Biomedicine - Category: Biotechnology Source Type: research
ConclusionQuite a few of the genes of the KIR, which are not uncommon in Indian population are also significantly associated with SLE in Indian patients. Few KIR genes can be used as biomarkers to understand the severity of the disease. The KIR genes in this cohort lead to decreased inhibitory signal and increased activation of NK cells and therefore causing increased apoptosis and formation of autoantibodies.
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research
ConclusionSLE was the most frequent cause of ICU admission; infections are the leading causes prompting admission. RDs patients often had multi-organ involvement with a high mortality rate.
Source: The Egyptian Rheumatologist - Category: Rheumatology Source Type: research
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