Lupus (Systemic Lupus Erythematosus)

Title: Lupus (Systemic Lupus Erythematosus)Category: Diseases and ConditionsCreated: 8/20/2013 2:45:00 PMLast Editorial Review: 5/8/2014 12:00:00 AM
Source: MedicineNet Arthritis General - Category: Rheumatology Source Type: news

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Publication date: Available online 12 December 2018Source: Life SciencesAuthor(s): Ashif Iqubal, Mohammad Kashif Iqubal, Sumit Sharma, Mohd. Asif Ansari, Abul Kalam Najmi, Syed Mansoor Ali, Javed Ali, Syed Ehtaishamul HaqueAbstractCyclophosphamide (CP) is an important anticancer drug which belongs to the class of alkylating agent. Cyclophosphamide is mostly used in bone marrow transplantation, rheumatoid arthritis, lupus erythematosus, multiple sclerosis, neuroblastoma and other types of cancer. Dose-related cardiotoxicity is a limiting factor for its use. CP-induced cardiotoxicity ranges from 7 to 28% and mortality ranges...
Source: Life Sciences - Category: Biology Source Type: research
This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Editorial Source Type: research
Publication date: Available online 5 December 2018Source: SeizureAuthor(s): Man Amanat, Roland Thijs, Mona Salehi, Josemir W. SanderAbstractThe risk of epileptic seizures seems increased in several systemic autoimmune disorders including systemic lupus erythematosus, type 1 diabetes mellitus, myasthenia gravis, celiac disease, rheumatoid arthritis, Hashimoto’s encephalopathy, psoriasis, multiple sclerosis, neuromyelitis optica, and bullous pemphigoid. Immune dysfunction may be partly responsible for this association. Elevated levels of pro-inflammatory cytokines, autoantibodies seen in these autoimmune disorders and ...
Source: Seizure - Category: Neurology Source Type: research
Although accumulating data have suggested the development of cancer in systemic lupus erythematosus (SLE) patients, these results remain inconsistent. To examine such a putative association, this analysis repo...
Source: Arthritis Research and Therapy - Category: Rheumatology Authors: Tags: Research article Source Type: research
Conditions:   Rheumatoid Arthritis;   Systemic Lupus;   Sjögren Syndrome;   Systemic Vasculitis;   Spondyloarthritis Interventions:   Biological: 13-valent pneumococcal conjugate vaccine;   Biological: 23-valent pneumococcal polysaccharide vaccine Sponsor:   Region Skane Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionThe U1 snRNP immune complex is a specific stimulus of MIF production in human monocytes, with MIF having an upstream role in defining the inflammatory characteristics of activated monocytes by regulating NLRP3 inflammasome activation and downstream IL ‐1β production. These findings provide mechanistic insight and a therapeutic rationale for targeting MIF in subgroups of lupus patients, such as those classified as high genotypicMIF expressers or those with anti ‐snRNP antibodies.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Original Article Source Type: research
ConclusionDendritic cell transcriptional signatures are altered in autoimmune patients and are associated with disease activity suggesting that immune cell transcriptional profiles could improve our ability to detect and understand the heterogeneity of disease pathology, as well as guide treatment choices in patients with complex autoimmune disease.This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Full Length Source Type: research
ConclusionDirect serum ‐IFNα determination with a highly sensitive assay might improve monitoring of clinical SLE activity and selection of the best candidates for anti‐IFNα treatment.This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Full Length Source Type: research
This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Review Article Source Type: research
Publication date: Available online 24 November 2018Source: Journal of Arthroscopy and Joint SurgeryAuthor(s): Meenakshi Jolly, Asha Patnaik, Courtney O'Brien, Anupam Basu, Augustine ManadanAbstractDifferential diagnosis for inflammatory arthritis of the hands includes infectious processes and autoimmune conditions like rheumatoid arthritis, systemic lupus erythematosus, and crystalline arthritis, among others. As medical management of the inflammatory arthritis is (a) targeted to the specific disease and severity of the symptoms, (b) posed with diagnostic dilemmas due to overlap in presentation, and (c) adversely affected ...
Source: Journal of Arthroscopy and Joint Surgery - Category: Orthopaedics Source Type: research
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