Lupus (Systemic Lupus Erythematosus)
Title: Lupus (Systemic Lupus Erythematosus)Category: Diseases and ConditionsCreated: 8/20/2013 2:45:00 PMLast Editorial Review: 5/8/2014 12:00:00 AM
Decreased expression of the TCR ζ-chain has been reportedin several autoimmune and inflammatory diseases. Recent evidence suggeststhat this deficiency may be due to polymorphisms in the CD247gene. A total 52 patients with systemic lupus erythematosus (SLE) and95 healthy controls of Bulgarian ethnicity were genotyped for 837C>G,rs1052230, 844A>T, and rs1052231 using a TaqMan genotyping assay.None of the two polymorphisms appeared associated with the diseases.On the other hand, we have found that the -837GG genotype and the Gallele were associated with hematological disease. The -844AA genotypeand the A allele app...
We describe three patients with ATIL. The first patient had a classical drug-induced lupus (DIL) presented by thrombocytopenia that resolved after infliximab discontinuation. The second case experienced symmetric polyarthritis of 14 joints in rheumatoid arthritis (RA)-like distribution accompanied by l ymphopenia. The third one had a severe serositis including ascites and pleural and pericardial effusions along with pancytopenia. In this patient, ATIL coexisted with anti-TNF-α-induced hepatitis. The second and third patients met the American College of Rheumatology classification criteria for SLE . Nevertheless, all ...
In conclusion, a rapid and robust method for the detection of IC was developed, which has numerous potential applications including the monitoring of IC in autoimmune diseases and the study of underlying FcγR biology. PMID: 29351998 [PubMed - as supplied by publisher]
Conditions: Lupus; Psoriatic Arthritis Interventions: Drug: Methotrexate; Drug: Leucovorin; Drug: BMS-986165 Sponsor: Bristol-Myers Squibb Not yet recruiting
ConclusionsMAS was most likely to develop concomitantly with cSLE diagnosis. The majority of the MAS patients were successfully treated with corticosteroids with no MAS relapses. Although the numbers were small, there was a higher risk of death associated with MAS compared to those without MAS.This article is protected by copyright. All rights reserved.
(Wiley) Pediatric rheumatic diseases are a varied group of rare diseases including juvenile forms of arthritis, lupus, fibromyalgia, and other conditions. Currently, there is considerable variability in how patients with these diseases are treated in clinical practice, making it difficult to understand which therapies work best.
This article is protected by copyright. All rights reserved.
Conclusions: The functions of IL-27 are currently unclear because it appears to affect different cells, cytokines, and signaling pathways differently. Further investigations are needed to clarify the role of IL-27 in autoimmune diseases. Hence, this article reviewed the multiple roles of IL-27 in autoimmune diseases and describe the influence of IL-27 on the immune system.
Hydralazine is an antihypertensive medication that has been associated with drug-induced lupus erythematosus (DIL) as well as ANCA-associated vasculitis (AAV). Although rare, early diagnosis is critical since drug cessation is the mainstay of therapy. This retrospective study aims to characterize the clinical, laboratory, and histopathologic features of this disease.
Sj ögren's syndrome (SS) is a systemic autoimmune disorder characterized by focal inflammation of the exocrine glands, leading to dry eyes and dry mouth. Two forms of the syndrome have been defined: primary (pSS), in which dysfunction of the exocrine glands occurs in the absence of other autoimmune di seases, and secondary, in which patients suffer additional autoimmune processes, especially connective tissue disorders such as rheumatoid arthritis, systemic lupus erythematosus and scleroderma. About 70% of patients with pSS have anti-Ro and/or anti-La autoantibodies.