Recurrent venous thrombosis under rivaroxaban and carbamazepine for symptomatic epilepsy

Conclusion The combination of DOACs with carbamazepine, an inducer of P-gp and CYP3A4-activity, should be avoided since the anticoagulant effect is decreased. There is an urgent need to increase our knowledge and physicians’ awareness about the potential of drug–drug interactions of DOACs.
Source: Polish Journal of Neurology and Neurosurgery - Category: Neurosurgery Source Type: research