Tumor and normal thyroid spheroids: from tissues to zebrafish.

CONCLUSIONS: We report the characterization of multicellular spheroids obtained from PTCs and normal thyroid tissues, showing that they are enriched in stem-like cells. Moreover, we established xenografts of spheroids in zebrafish, demonstrating that they stimulate neoangiogenesis. This in vivo model could be considered as a valuable platform to test the effects of anticancer drugs.
PMID: 28146140 [PubMed - as supplied by publisher]

Source: Minerva Endocrinologica - February 3, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research