Health Care Special Report: Children ’s Mercy platform targets ‘Goldilocks’ doses

For some treatments, the perfect dose is a necessity. Leukemia patients, for example, take busulfan to prepare for a bone marrow transplant. Too little, and the patient ’s body won’t accept the transplant. Too much, however, can cause irreversible liver damage. “It’s a really fine line,” said Susan Abdel-Rahman, director of the pharmacokinetic and pharmacodynamics core laboratory at Children’s Mercy. She created a platform to help determine how much i s “just right” based on a child’s…
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