Health Care Special Report: KU doc finds cancer hope

After years of treating patients, researching cancer and testing treatments, Tomoo Iwakuma made the discovery of his lifetime: Statins, typically used to lower cholesterol levels, could treat some types of cancer. An associate professor at the University of Kansas Medical Center, Iwakuma thinks that statins — such as brand names Crestor and Lipitor — could be used to treat 10 to 20 percent of cancer patients with a mutation in a tumor suppressor protein called p53. This mutation is found in…
Source: Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news

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ConclusionsHigh statin users with hypercholesterolemia were associated with lower risk of overall colorectal cancer, especially proximal colon cancer in men and rectal cancer in both sexes.
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Taking statins before or after cancer diagnosis cuts all - cause and cancer - related deaths
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Cardiology, Family Medicine, Gastroenterology, Internal Medicine, Oncology, Pharmacy, Journal, Source Type: news
ConclusionsNo evidence of an association between the use of metformin or statins and the incidence of breast cancer in women with T2D was found. Among insulin users, a slightly higher incidence of breast cancer was observed.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
ConclusionMonthly high-dose vitamin D supplementation does not prevent a range of diseases, but may be beneficial for some intermediate outcomes in people who are vitamin D deficient.Trial registrationAustralian New Zealand Clinical Trials Registry identifier: ACTRN12611000402943.
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research
In conclusion, the results of the present study reveal the possible molecular mechanism of simvastatin-induced anti-tumor effects in C666-1 and suggest that simvastatin is a potential chemotherapy agent in NPC treatment. PMID: 31105786 [PubMed]
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
ConclusionAspirin use may have chemo-preventive effect on recurrence of hepatitis B virus-related HCC after curative resection.
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
CONCLUSION: Aspirin use may have chemo-preventive effect on recurrence of hepatitis B virus-related HCC after curative resection. PMID: 31104872 [PubMed - as supplied by publisher]
Source: J Formos Med Assoc - Category: General Medicine Authors: Tags: J Formos Med Assoc Source Type: research
Simvastatin delays castration‑resistant prostate cancer metastasis and androgen receptor antagonist resistance by regulating the expression of caveolin‑1. Int J Oncol. 2019 Jun;54(6):2054-2068 Authors: Gao Y, Li L, Li T, Ma L, Yuan M, Sun W, Cheng HL, Niu L, Du Z, Quan Z, Fan Y, Fan J, Luo C, Wu X Abstract The failure of androgen deprivation therapy in prostate cancer treatment mainly results from drug resistance to androgen receptor antagonists. Although an aberrant caveolin‑1 (Cav‑1) expression has been reported in multiple tumor cell lines, it is unknown whether it is responsible for t...
Source: International Journal of Oncology - Category: Cancer & Oncology Authors: Tags: Int J Oncol Source Type: research
This study evaluates the impact of duration of statin use on breast cancer patient outcomes.MethodsThis is a single-institution, retrospective cohort, examining the impact of statin use on the outcomes of 1523 women diagnosed with operable breast cancer between1995 and 2015. Clinical variables were compared using Student ’st test, Fisher ’s exact and Chi square tests. Overall (OS) and disease-free (DFS) survival were performed using Kaplan–Meier and Cox-Proportional Hazard (Cox-PH) analysis in the statistical softwareR.ResultsPatients were grouped by duration of statin use: never-statin user [N] (n&thinsp...
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
Abstract Emergence of novel treatment modalities provides effective therapeutic options, apart from conventional cytotoxic chemotherapy, to fight against colorectal cancer. Unfortunately, drug resistance remains a huge challenge in clinics, leading to invariable occurrence of disease progression after treatment initiation. While novel drug development is unfavorable in terms of time frame and costs, drug repurposing is one of the promising strategies to combat resistance. This approach refers to the application of clinically available drugs to treat a different disease. With the well-established safety profile and...
Source: Cellular and Molecular Life Sciences : CMLS - Category: Cytology Authors: Tags: Cell Mol Life Sci Source Type: research
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