Challenges with Mosquito-borne Viral Diseases: Outbreak of the Monsters.

Challenges with Mosquito-borne Viral Diseases: Outbreak of the Monsters. Curr Top Med Chem. 2017 Jan 30; Authors: Gautam R, Mishra S, Milhotra A, Nagpal R, Mohan M, Singhal A, Kumari P Abstract The viruses responsible for mosquito-borne diseases are on an exploring mode, expanding their horizon, adapting to the situation and comfortably making their presence felt globally, from South Africa to Asia, Europe and United States. The current global scenario and recent documentations indicate towards the real monsters, outbreak of Zika, dengue and chikungunya viruses. Zika, dengue and chikungunya viruses, all three are positive sense single-stranded RNA arbovirus and so their initial symptoms are almost 80% similar and all three are spread by mosquitos which bite during the day. Zika virus is more dangerous for pregnant women as it is suspected to cause brain damage in babies by targeting their neuron cells. A less common but highly dangerous type of Dengue is the one which causes hemorrhagic fever (DHF) and shock syndrome (DSS) which are lethal. Chikungunya is not as lethal as Zika and Dengue are, but it triggers joints pain which could last for months and even for years. There is no line of treatment for all three viruses and their vaccines are at different stages of development. The challenges associated with the epidemic wave of Zika, dengue and chikungunya viruses have been explained and the current status of drug/ vaccine development against these viruse...
Source: Current Topics in Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Top Med Chem Source Type: research

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Publication date: Available online 15 July 2019Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Emad I. Wafa, Sean M. Geary, Kathleen A. Ross, Jonathan T. Goodman, Balaji Narasimhan, Aliasger K. SalemAbstractThe primary objective of this study was to enhance the antitumor efficacy of a model cancer vaccine through co-delivery of pentaerythritol lipid A (PELA), an immunological adjuvant, and a model tumor antigen, ovalbumin (OVA), separately loaded into polyanhydride particles (PA). In vitro experiments showed that encapsulation of PELA into PA (PA-PELA) significantly enhanced its stimulatory capacity on...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research
ConclusionsThe result showed that sampling region, fish status, fish species and sampling month were the main factors influencing infection rate. Regulations or guidelines are urgent in China for the control of Anisakis spp. infection in marine fish.
Source: Food Control - Category: Food Science Source Type: research
Authors: Sarkar R, Paul R, Thakur I, Ghosh R, Singh S, Mani A, Sau TJ, Lahiri G Abstract Dengue virus induced encephalitis is a very rare entity and its full clinicoradiological profile is still unknown. We here report two cases of dengue encephalitis from Eastern India. The first one is a 20 year old female and the second one is a 13 year old boy. Both of them presented with altered consciousness and seizures. Blood and CSF study for dengue IgM were positive. MRI of brain showed T2 hyperintensity in the Thalami along with similar changes in other parts of the brain. Both patients responded to conservative therapy ...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Authors: Mian A, Singal AK, Bakhshi S, Sood R, Vikram NK, Ray A Abstract A 21-year old female, recently diagnosed with osteosarcoma of right humerus, presented to the emergency with history of fever, productive cough, chest pain and progressive respiratory distress for six days. Initial investigations suggested pneumonia but she did not respond to parenteral antibiotics. CT pulmonary angiogram revealed bilateral pulmonary artery embolism. Thrombolysis was performed using alteplase, which failed to improve the clinical condition. In view of underlying malignancy, a possibility of tumour-embolism was considered and s...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Conclusion: Increased incidence of dengue fever with encephalopathy in the recent years, in the absence of single sensitive test for detecting dengue encephalopathy, variable CSF and MRI Brain features, and associated high morbidity and mortality poses a big problem for clinician. This study may be helpful in focussing on early diagnosis and aggressive initial management which can influence final outcome. PMID: 31299837 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Authors: Sharma R, Mahajan SK, Singh B, Raina R, Kanga A Abstract Aims: To study predictors of severity in patients of scrub typhus admitted in a tertiary care hospital. Material and Methods: Total 92 patients of scrub typhus were included in the study. The diagnosis was established by presence of IgM antibodies by Indirect Immunofluorescence Assay (IFA) test which is currently the reference standard for the diagnosis of scrub typhus. The clinical and laboratory profile, course in hospital, and outcome were documented. Factors associated with severe disease were analyzed. Observations: Fever (100%), cough (...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
This study was conducted in a tertiary health care centre in North India over 18 months. Data of hospitalized patients who admitted with dengue fever diagnosis in a peak season was collected in the form of quality indicators as described by the WHO-2009 guideline on dengue. Resident physicians were then given appropriate training about the guideline during the off season. Data of new dengue patients in next peak season after resident training was collected and compared with the baseline by standard statistical tests. Results: The post-intervention compliances of all components increased (total mean score by giving one ...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Conclusion: There is a need to focus on improving adherence among type 2 diabetes patients and strengthening health care systems for regular supply of medicines and provide health education to the patients and their families emphasising the need of adherence to medications. PMID: 31299834 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Publication date: Available online 13 July 2019Source: Biosensors and BioelectronicsAuthor(s): J.R. Anusha, Byung Chul Kim, Kook-Hyun Yu, C. Justin RajAbstractDengue virus is a mosquito-borne, single positive-stranded RNA virus that spread human being through infected female Aedes mosquito bite and causes dengue fever. The demand for early detection of this virus has increased to control the widespread of infectious diseases and protect humanity from its harmful effects. Recently, biosensors are found to the potential tool to detect and quantify the virus with fast detection, relatively cost-effective, high sensitivity and...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
[WHO] Brazzaville, 15 July 2019 - The World Health Organization (WHO) is scaling up operations in Burkina Faso in response to a growing humanitarian crisis, which has seen over 200,000 displaced. WHO is mobilizing experts to strengthen interventions, including preventative and responsive vaccination campaigns and strategies for provision of health services, as well as increasing supplies of medicines and medical equipment.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
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