Bone mass loss is associated with systolic blood pressure in postmenopausal women with type 2 diabetes in Tibet: a retrospective cross-sectional study

ConclusionsAmong diabetic postmenopausal women dwelling in high altitude, 27.3% patients have osteoporosis, 42.4% patients have osteopenia, and 30.3% are normal. The BMD T-score of spine was inversely associated with SBP and positively associated with HbA1c, while the BMD T-score of femoral neck or hip was inversely associated with ages and SBP.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research

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This study is a post-hoc analysis of steroid hormones before and after administration of pharmacological doses of soy isoflavones in a large cohort of men and women from two independent studies. Isoflavones are reported to inhibit mineralo- and glucocorticoid hormone production as well as reproductive steroids in vivo and in vitro. We focused on cytochrome P450 17α-hydroxylase (CYP17A1) which catalyses the production of dehydroepiandrosterone (DHEA), in the androgen biosynthesis pathway to elucidate effects on sex steroids in vitro. Design and Setting: Effects of soy isoflavones on steroid levels in two studies comp...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
A 60-year-old multi-morbid male patient with polycystic kidney disease and secondary chronic renal insufficiency stage G5 A3 according to Kidney Disease: Improving Global Outcomes (KDIGO) classification was referred to our hospital with radiological differential diagnoses of sarcoidosis, ectasia of the pulmonary arteries, lymphoma, or central bronchial carcinoma with contralateral hilar lymph node metastases. He had concomitant arterial hypertension, manifest osteoporosis due to renal osteopathy, secondary compensated renal hyperparathyroidism, compensated metabolic renal acidosis, and diabetes mellitus type 2.
Source: Heart, Lung and Circulation - Category: Cardiology Authors: Tags: Image Source Type: research
ConclusionsLower vBMD was associated with increased all-cause mortality in African-American men with T2D, independent of other risk factors for mortality including subclinical atherosclerosis.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
CONCLUSIONS: Safer and more effective systemic treatment options are needed for pemphigus to minimize iatrogenic complications of disease. PMID: 29447647 [PubMed - in process]
Source: Dermatol Online J - Category: Dermatology Authors: Tags: Dermatol Online J Source Type: research
ABSTRACT Obesity is a growing epidemic both in Australia and worldwide. Being overweight or obese is known to be adversely associated with multiple cardiovascular risk factors such as type 2 diabetes mellitus, lipid disorders and hypertension. Despite the adverse impact of overweight and obesity, recent observational studies have suggested that in some overweight and obese individuals with established chronic disease, there is a survival advantage which is paradoxically better than individuals of normal weight. A burgeoning area of interest is the existence of this paradox in chronic endocrine disorders, especially with re...
Source: Internal Medicine Journal - Category: Internal Medicine Authors: Tags: Review Source Type: research
In conclusion, hTERT expression strictly limits telomerase activation in most of somatic cells, whereas mTERT expression is detectable in most of mouse tissue cells. The interspecies differences between human and mice suggest an improved mouse line, in which both telomerase regulation and telomere length controls are humanized, would considerably benefit the studies of human aging and cancer using mouse models. ON CELLULAR REPROGRAMMING AND CELLULAR REJUVENATION https://www.fightaging.org/archives/2016/07/on-cellular-reprogramming-and-cellular-rejuvenation/ The commentary linked below takes a look at some rece...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Authors: Chiodini I, Morelli V Abstract Subclinical hypercortisolism (SH) is a condition of mild cortisol excess, found in the 5-30% of patients with adrenal incidentalomas, defined as silent adrenal masses diagnosed throughout radiological examinations performed for unrelated diseases. Generally, the diagnosis of SH is supported by the presence of high cortisol levels after a 1-mg dexamethasone suppression test, low adrenocorticotropic hormone levels, altered cortisol circadian rhythm and 24-hour urinary free cortisol levels higher than the upper reference value. Less frequently, diagnosis is made by other tests. ...
Source: Frontiers of Hormone Research - Category: Endocrinology Tags: Front Horm Res Source Type: research
CONCLUSIONS: Acute anterior uveitis in SpA predominantly affects males with AS. This is relevant both to clinical and fundamental science, since its management requires both ophthalmology and rheumatology clinical settings. Psoriasis was associated more frequently with peripheral SpA. ABBREVIATIONS: AHT = arterial hypertension, AS = ankylosing spondylitis, ASAS = Assessment in SpondyloArthritis international Society, aSpA = axial spondyloarthritis, BASFI = Bath Ankylosing Spondylitis Functional Index, BASDAI = Bath Ankylosing Spondylitis Disease Activity Index, CRP = C-reactive protein, ESR = erythrocyte sedimentation ...
Source: Journal of Medicine and Life - Category: Journals (General) Tags: J Med Life Source Type: research
Abstract ObjectiveGrowing evidence suggests the presence of a complex interplay between hypertension as well as type 2 diabetes mellitus (DM) and osteoporosis. The present study was designed to investigate a possible effect of type 2 DM on bone remodelling markers such as osteoprotegerin and N‐terminal propeptide of type 1 collagen (P1NP) in hypertensive patients. Design and MethodsThe 100 study participants were divided into three groups according to the presence of DM and hypertension: group one included diabetic hypertensive subjects, group 2 included hypertensive subjects without diabetes and group 3 included subject...
Source: Diabetes/Metabolism Research and Reviews - Category: Endocrinology Authors: Tags: Research Article Source Type: research
Abstract ObjectiveGrowing evidence suggests the presence of a complex interplay between hypertension as well as type 2 diabetes mellitus (DM) and osteoporosis. The present study was designed to investigate a possible impact of type 2 DM on bone remodeling markers such as osteoprotegerin (OPG) and N‐terminal propeptide of type 1 collagen (P1NP) in hypertensive patients. Design and MethodsThe 100 study participants were divided into three groups according to presence of DM and hypertension: group one included diabetic hypertensive subjects, group 2 included hypertensive subjects without diabetes and group 3 included subjec...
Source: Diabetes/Metabolism Research and Reviews - Category: Endocrinology Authors: Tags: Research Article Source Type: research
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