Protective Effects of Bexarotene against Amyloid-β25-35-Induced Dysfunction in Hippocampal Neurons through the Insulin Signaling Pathway.

Conclusion: The effects of bexarotene on Aβ-impaired excitability and sAP duration were mainly associated with K(+) channels through insulin signaling pathway, which may be an additional mechanism underlying the protective effect of bexarotene on AD. © 2014 S. Karger AG, Basel.
PMID: 24802415 [PubMed - as supplied by publisher]

Source: Neuro-Degenerative Diseases - April 30, 2014 Category: Neurology Authors: Dai W, Yang J, Chen T, Yang Z Tags: Neurodegener Dis Source Type: research