Epidemiology of Otitis Media with Spontaneous Perforation of the Tympanic Membrane in Young Children and Association with Bacterial Nasopharyngeal Carriage, Recurrences and Pneumococcal Vaccination in Catalonia, Spain - The Prospective HERMES Study

by Robert Cilveti, Montserrat Olmo, Josefa P érez-Jove, Juan-José Picazo, Josep-Lluis Arimany, Emiliano Mora, Tomás M. Pérez-Porcuna, Ignacio Aguilar, Aurora Alonso, Francesc Molina, María del Amo, Cristina Mendez, on behalf of the HERMES Study Group The Epidemiology of otitis media with spontaneous perforation of the tympanic membrane and associated nasopharyngeal carriage of bacterial otopathogens was analysed in a county in Catalonia (Spain) with pneumococcal conjugate vaccines (PCVs) not included in the immunization programme at study time . A prospective, multicentre study was performed in 10 primary care centres and 2 hospitals (June 2011-June 2014), including all otherwise healthy children ≥2 months ≤8 years with otitis media presenting spontaneous tympanic perforation within 48h. Up to 521 otitis episodes in 487 children were included, showing by culture/PCR in middle ear fluid (MEF):Haemophilus influenzae [24.2%], bothStreptococcus pneumoniae andH.influenzae [24.0%],S.pneumoniae [15.9%],Streptococcus pyogenes [13.6%], andStaphylococcus aureus [6.7%]. Culture-negative/PCR-positive otitis accounted for 31.3% (S.pneumoniae), 30.2% (H.influenzae) and 89.6% (mixedS.pneumoniae/H.influenzae infections). Overall, incidence decreased over the 3-year study period, with significant decreases in otitis byS.pneumoniae and byH.influenzae, but no decreases for mixedS.pneumoniae/H.influenzae infections. Concordance between species in nasopharynx and MEF was found in 58.3% ...
Source: PLoS One - Category: Biomedical Science Authors: Source Type: research