Amnesia and hippocampal ischemia in 4 opiate abusers: a case series

Hippocampus (wikipedia.org) 3.5 out of 5 stars Complete, bilateral hippocampal ischemia: a case series. Small JE et al. Neruocase 2016 Oct;22:411-415. Abstract Last week, we reviewed an MMWR investigation into a cluster of 14 cases of acute anterograde amnesia with MRI evidence of bilateral hippocampal ischemia identified in Massachusetts during the years 2012-2016. This constellation of features is distinctly unusual — especially when symmetric and accompanied by scant pathology outside the hippocampus —  but has in the past been associated with cocaine abuse and carbon monoxide poisoning. The MMWR review contained limited clinical information. This paper, from Lahey Medical Center in Burlington MA, describes the initial 4 cases ins somewhat more detail. Some key features of these cases: Three patients had opiate-positive drug screens (the other had a history of opiate abuse but no drug screen was sent) Two patients were unresponsive when brought to hospital (the other 2 had abrupt-onset amnesia but no history of unconsciousness) Neurological deficits persisted to some extent on long-term follow-up in two patients (one of the others died before repeat test, the fourth did not return to clinic) The authors propose that “MRI finding of acute pyriform ischemia in the hippocampi should be considered strongly suggestive of a toxic exposure.” While they concede that these 4 cases do not prove a causative link between abu...
Source: The Poison Review - Category: Toxicology Authors: Tags: Medical amnesia hippocampus ischemia memory opiate abuse Source Type: news

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CONCLUSIONS: Our findings support the protective effect a normal weight against advanced adenomas. Reduction of BMI value should be pursued in healthy programs. PMID: 32233893 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
Conclusion: There is a slightly increasing trend in the occurrence of esophageal perforations. Contemporary treatment is less invasive with similar results. Patients treated in high-volume hospitals have better prognosis. PMID: 32233883 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
Conclusion: Abstinence from alcohol following AC/AH diagnosis was achieved in 39% of patients. Abstinence was not related to increased survival for alcoholic liver disease patients at one-year, which might partly indicate that this might be a marker that some patients were 'too sick to drink'. AC and AH patients who survived one year and remained abstinent had a favorable long-term prognosis. PMID: 32233877 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
Authors: Møller S, Kimer N, Barløse M, Bendtsen F Abstract Detailed knowledge and understanding of the pathophysiological mechanisms and changes in hepatic and splanchnic function leading to the development of haemodynamic changes and portal hypertension in patients with cirrhosis are essential since it guides the search for targets to ameliorate liver-related abnormalities. Recent research has focused on the gut-liver axis, changes in intestinal permeability, translocation of bacterial products, and inflammation as important drivers of haemodynamic alterations and thereby targets for treatment. Addit...
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
Authors: Freitas M, Arieira C, Carvalho PB, Rosa B, Moreira MJ, Cotter J Abstract Background: Capsule endoscopy is a widely recognized method to study the small bowel, including in patients with Crohn's disease (CD). The Lewis score (LS) is a valuable tool in this setting, able to assess inflammatory activity. TOP100, a new software tool of the RAPID Reader®, emerged to assist in the time-consuming capsule reading process, by automatically selecting 100 images that will most likely contain abnormalities.Aim: Evaluate the agreement between TOP100 and classic reading (CR) in determining LS in the setting of CD.Me...
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
Abstract Advances in medical devices have allowed the use of CT, MRI, and PET-CT for the diagnosis of tumors and the detailed evaluation of the extent of lesions. For several decades, CT has been established as the gold standard modality for the treatment planning of radiotherapy, while MRI has emerged as a tool to evaluate the functional characteristics of tumors without radiation exposure. To further optimize precision radiation therapy, we should consider how functional images can be used in the workflow for radiation therapy. In this regard, MRI, as a modality without the need for a contrast agent, may allow m...
Source: Igaku Butsuri: Japanese Journal of Medical Physics - Category: Physics Authors: Tags: Igaku Butsuri Source Type: research
Abstract Ayurveda oil contains numerous source of biological constituents which plays an important role in reducing the pain relief caused during bone fracture. The aim of the study is to fabricate the polyurethane (PU) scaffold for bone tissue engineering added with ayurveda amla oil using electrospinning technique. Scanning Electron Microscopy (SEM) analysis showed that the fabricated nanocomposites showed reduced fiber diameter (758 ± 185.46 nm) than the pristine PU (890 ± 116.91 nm). Fourier Infrared Analysis (FTIR) revealed the existence of amla oil in the PU matrix by hydrogen bond formation. T...
Source: An Acad Bras Cienc - Category: Science Authors: Tags: An Acad Bras Cienc Source Type: research
This report describes 2 cases of primary renal carcinoid tumor with unique presentations and management in our regional health care system. Because primary renal carcinoid tumors are quite uncommon, there are no clear established guidelines on preoperative imaging or posttreatment surveillance in patients with these tumors. There remains a large amount of variability in the diagnosis, workup, immunohistochemical analysis, treatment, and surveillance of patients with primary renal carcinoid tumors. As we learn more about this disease, we hope to optimize patient outcomes and standardize pretreatment workup and posttreatment...
Source: The Permanente journal - Category: General Medicine Tags: Perm J Source Type: research
Hippocampus (wikipedia.org) 3 out of 5 stars An Unusual Amnesic Syndrome Associated With Combined Fentanyl and Cocaine Use. Duru LB et al. Ann Intern Med 30 Jan 2018 [Epub ahead of print] Reference Last year we reviewed an MMWR report describing 14 cases of anterograde amnesia associated with substance abuse and bilateral ischemia of the hippocampi, as well as an additional paper giving somewhat more detailed clinical information on the initial four cases. This letter describes an additional case that occurred in West Virginia. A 30-year-old man with a history of heroin use was found at home to be difficult to ar...
Source: The Poison Review - Category: Toxicology Authors: Tags: Medical cocaine fentanyl hippocampus hippocampus ischemia norfentanyl opiate opioid Source Type: news
Hippocampus (wikipedia.org) 3.5 out of 5 stars Complete, bilateral hippocampal ischemia: a case series. Small JE et al. Neruocase 2016 Oct;22:411-415. Abstract Last week, we reviewed an MMWR investigation into a cluster of 14 cases of acute anterograde amnesia with MRI evidence of bilateral hippocampal ischemia identified in Massachusetts during the years 2012-2016. This constellation of features is distinctly unusual — especially when symmetric and accompanied by scant pathology outside the hippocampus —  but has in the past been associated with cocaine abuse and carbon monoxide p...
Source: The Poison Review - Category: Toxicology Authors: Tags: Medical amnesia hippocampus ischemia memory opiate abuse Source Type: news
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