p -Hydroxyacetophenone suppresses nuclear factor- κB-related inflammation in nociceptive and inflammatory animal models

This study investigated the antioxidative, antinociceptive, and anti-inflammatory effects of HAP, and probed its possible molecular mechanisms. Our results revealed that HAP (80  mg/kg, intraperitoneally) in vivo reduced the acetic acid-induced writhing response and formalin-induced licking time. Moreover, in the λ-carrageenan-induced acute-inflammatory paw edema model in mice, HAP significantly improved hind paw swelling and neutrophil infiltration. In a homogenized paw tissue examination, HAP attenuated pro-inflammatory cytokines, such as tumor necrosis factor-α, interleukin-1β, and interleukin-6. Simultaneously, HAP also inhibited the production of nuclear factor kappa B, cyclooxygenase-2, and nitric oxide (NO). Another examination revealed that HAP exerted ant i-inflammatory activity by decreasing malondialdehyde levels in the edematous paw through increasing the activities of superoxide dismutase, glutathione peroxidase, and glutathione reductase in the liver. These findings may be beneficial in understanding the therapeutic effects of some plants of the genusArtemisia in the pretreatment of inflammation-associated diseases.
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research

Related Links:

Publication date: Available online 9 November 2019Source: Journal of Applied Research on Medicinal and Aromatic PlantsAuthor(s): Zahra Gharari, Khadijeh Bagheri, Hossein Danafar, Ali SharafiAbstractScutellaria is a diverse and widespread genus of the Lamiaceae family of herbaceous plants known commonly as skullcaps. It has been implicated for medicinal purposes for the treatment of various ailments ranging from cancers, nervous disorders, hepatitis, anxiety and jaundice. A sensitive, simple and reliable high performance liquid chromatography (HPLC) method was developed for simultaneous quantification of three major active ...
Source: Journal of Applied Research on Medicinal and Aromatic Plants - Category: Complementary Medicine Source Type: research
Acute liver disease or failure in children is the result of viral hepatitis (A, B, E, seronegative), indeterminate hepatitis or inherited metabolic liver disease. The clinical presentation includes jaundice, coagulopathy and encephalopathy. Uncomplicated acute hepatitis resolves spontaneously, but progressive acute liver failure is fatal in 70% of cases and requires referral to specialized units to prevent complications and for consideration for liver transplantation. Chronic liver disease can result from unresolved neonatal liver disease caused by either inherited cholestasis or α1-antitrypsin deficiency.
Source: Medicine - Category: Internal Medicine Authors: Tags: Mothers, babies and children Source Type: research
Autoimmune hepatitis (AIH) is an acute or chronic liver disease that causes significant inflammation at a cellular level and leads to cirrhosis if left untreated. The basis of diagnosis is increased liver enzymes and immunoglobulins with positive autoantibodies and necroinflammatory changes on liver biopsy. Clinical presentations can vary. Asymptomatic patients may only have raised liver enzymes detected on routine testing, the other extreme of presentation being represented by fatigue, jaundice and liver failure.
Source: Medicine - Category: Internal Medicine Authors: Tags: Autoimmune liver disease Source Type: research
Publication date: November 2019Source: Arabian Journal of Chemistry, Volume 12, Issue 7Author(s): Chinaka O. Nwaehujor, Julius O. Ode, Mercy R. Ekwere, Rita I. UdegbunamAbstractThe methanol root extracts of Carica papaya (Pawpaw) are used in eastern Nigeria for the treatment of malaria, hepatitis and jaundice. The aim of this study was to investigate the effects of the fractions isolated from C. papaya methanol root extract on fertility in male Wistar rats using sperm counts, percentage defective sperm cells (morphology), biochemical and hormonal assays as biomarkers. The roots of C. papaya were extracted using 80% methano...
Source: Arabian Journal of Chemistry - Category: Chemistry Source Type: research
BOSTON (CBS) – Packages of frozen raspberries and frozen berry mixes containing raspberries sold at Aldi Grocery Stores are being recalled because they could be contaminated with Hepatitis A. Wawona Frozen Foods in California issued the voluntary recall for the berries sold in bags with the Season’s Choice label. No one has reported getting sick, but the recall was issued “out of an abundance of caution due to a positive test result taken as part of a government sampling program.” If you have the berries, don’t eat them. Instead throw them out or return them to the store for a refund. The reca...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Consumer Health Syndicated CBSN Boston Syndicated Local Aldi Hepatitis A Recalls Source Type: news
Rationale: Fusidic acid (FA) is an active agent against gram-positive bacteria such as Staphylococcus, it is generally well tolerated and the major adverse effects are mild gastrointestinal discomfort, diarrhea, and headache. However, some rare side effects such as granulocytopenia and thrombocytopenia have also been reported. Here we report a case of FA-induced hepatotoxicity and hematologic toxicity. Patient concerns: A 54-year-old woman with hepatitis B cirrhosis was referred to us because of fever, Staphylococcus aureus was identified in the twice blood culture, and intravenous FA was given (0.5 g, q8 hours). ...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Idiosyncratic drug-induced liver injury (DILI) is an underreported and underestimated adverse drug reaction. A recent population-based study found a crude incidence of approximately 19 cases per 100,000 a year. Amoxicillin-clavulanate continues to be the most commonly implicated agent in most Western countries, reported to occur in approximately 1 of 2300 users. In patients with drug-induced autoimmune hepatitis, liver tests often do not normalize with cessation of the drugs and require corticosteroids. DILI associated with jaundice can lead to death from liver failure or require liver transplantation in at least 10% of cases.
Source: Clinics in Liver Disease - Category: Gastroenterology Authors: Source Type: research
Asymptomatic abnormal liver function tests (LFTs) are common, affecting 8% of the population. They are mainly caused by alcoholic liver disease and non-alcoholic fatty liver disease, whereas jaundice is most commonly caused by extrahepatic biliary obstruction, followed by alcoholic liver disease and acute liver injury from drugs or viruses. A careful history helps to exclude non-hepatic causes of abnormal LFTs, as well as indicating a potential hepatic cause. Cirrhosis can present with ascites or jaundice, the latter being common in alcoholic liver disease as a result of added injury from alcoholic hepatitis.
Source: Medicine - Category: Internal Medicine Authors: Tags: Assessment of liver disease Source Type: research
Publication date: Available online 16 October 2019Source: Journal of EthnopharmacologyAuthor(s): Zhiyong Zhang, Yiru Miao, Min Xu, Wenming Cheng, Chuanyan Yang, Xiangjian She, Qianqian Geng, Qunlin ZhangAbstractEthnopharmacological relevanceTianJiu (TJ) therapy, one type of cold moxibustion, applies to specific acupuncture points with herbal patches of hot nature, providing a constant irritant to the skin until the presence of hyperemia and blistering. Traditional and clinical reports suggest that TJ is an effective therapy for the treatment of jaundice with fresh Ranunculus sceleratus L. (RS), in which protoanemonin is on...
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Authors: Barcelos STA, Dall'Oglio VM, de Araújo A, Cerski CTS, Álvares-da-Silva MR Abstract Hepatic sinusoidal obstruction syndrome (HSOS) is a hepatic vascular disease histologically characterized by edema, necrosis, detachment of endothelial cells in small sinusoidal hepatic and interlobular veins and intrahepatic congestion, which leads to portal hypertension and liver dysfunction. In the Western world, most HSOS cases are associated with myeloablative pretreatment in a hematopoietic stem cell transplantation setting. Here we report a case of a 54 years old female patient, otherwise healthy, with n...
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
More News: Acetic Acid | Chemistry | Drugs & Pharmacology | Hepatitis | Jaundice | Liver | Study | Urology & Nephrology