Docking and QSAR studies of 1,4-Dihydropyridine derivatives as anticancer agent.

CONCLUSION: The predictive ability of the models was found to be satisfactory and could be used for designing new 1,4-dihydropyridines as potent MDR inhibitors in cancer treatment. 1,4- dihydropyridine ring containing protonable nitrogen as scaffold could be proposed. Sulfur, ester, amide, acyle, ether … fragments are connected to a 1,4-dihydropyridine ring. Phenyl groups (with an electronegative substituent) as a lipophilic part are essential for the inhibitory effect. PMID: 28137213 [PubMed - as supplied by publisher]
Source: Recent Patents on Anti-Cancer Drug Discovery - Category: Cancer & Oncology Tags: Recent Pat Anticancer Drug Discov Source Type: research