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Low Vitamin D Worsens Lupus Risks in Kids (CME/CE)

(MedPage Today) -- Children with lupus commonly are vitamin D deficient, which may contribute to their heightened inflammatory status and cardiovascular risk, researchers reported.
Source: MedPage Today Pediatrics - Category: Pediatrics Source Type: news

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A new study examines the role of vitamin D deficiency in the organ inflammation and damage that occurs in systemic lupus erythematosus.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Lupus Source Type: news
Publication date: Available online 3 November 2017 Source:Autoimmunity Reviews Author(s): Yehuda Shoenfeld, Roberto Giacomelli, Shir Azrielant, Onorina Berardicurti, John A. Reynolds, Ian N. Bruce Over the past 20years, much has been written about the potential role of vitamin D in on adverse health outcomes. In recent years, evidence has accumulated regarding the effect of vitamin D on the immune system, and its different cells. Some studies have noted lower vitamin D concentrations in patients with SLE. These epidemiological data still not answer the question: is vitamin D deficiency the cause or the effect? To answer t...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
The objective of this systematic review was to analyze clinical trials carried out for the investigation of the effect of vitamin D supplementation on systemic lupus erythematosus. The research was performed from August to September 2016, without limits regarding year of publication, restriction of gender, age, and ethnicity. For the guiding question, the PICO strategy was employed. To evaluate the quality of the publications the PRISMA protocol and Jadad scale were used. The risk of bias analysis of the clinical trials was performed using the Cochrane collaboration tool. After the process of article selection and removal ...
Source: Revista Brasileira de Reumatologia - Category: Rheumatology Source Type: research
AbstractVitamin D plays a key role in skeletal and cardiovascular disorders, cancers, central nervous system diseases, reproductive diseases, infections, and autoimmune and dermatological disorders. The two main sources of vitamin D are sun exposure and oral intake, including vitamin D supplementation and dietary intake. Multiple factors are linked to vitamin D status, such as Fitzpatrick skin type, sex, body mass index, physical activity, alcohol intake, and vitamin D receptor polymorphisms. Patients with photosensitive disorders tend to avoid sun exposure, and this practice, along with photoprotection, can put this categ...
Source: American Journal of Clinical Dermatology - Category: Dermatology Source Type: research
CONCLUSION: The literature does not show significant differences between the PS and PsA groups in terms of serum 25-OHD levels and a prevalence of Vitamin D deficiency. Besides, PASI scores were higher in the PS group. CRP values in the PsA group were higher than in the PS group. There was a poor negative correlation between CRP and serum 25-OHD levels in the PsA group. This correlation was not found in the PS group. PMID: 28946518 [PubMed - as supplied by publisher]
Source: Journal of Back and Musculoskeletal Rehabilitation - Category: Orthopaedics Tags: J Back Musculoskelet Rehabil Source Type: research
FACT: A vitamin D deficiency may result in as much as a 50 percent increased potential for diabetes. FACT: A vitamin D deficiency puts you at a higher risk for cancer, especially breast, prostate, colon, ovarian, and melanoma. VITAMIN D DEFICIENCY is a widespread phenomenon with significant implications for health. In modern society vitamin D deficiency is the rule, rather than the exception. While we can blame more severe cases of deficiency on grains, it also commonly occurs independent of grain consumption. The restoration of vitamin D levels is second only to grain elimination when considering the most powerful healthy...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Cancer Depression Diabetes News & Updates Undoctored Vitamin D Weight loss Source Type: blogs
Conclusions Women with SLE had a high prevalence of vitamin D insufficient. No association between vitamin D levels and disease activity was found.
Source: Reumatologia Clinica - Category: Rheumatology Source Type: research
by Marina Eloi, Daniela Vargas Horvath, Jo ão Carlos Ortega, Mônica Simon Prado, Luis Eduardo Coelho Andrade, Vera Lúcia Szejnfeld, Charlles Heldan de Moura Castro We aim to evaluate the prevalence of vitamin D deficiency in patients with systemic lupus erythematosus (SLE) and investigate the association between total, free and bioavailable vitamin D serum concentrations and disease activity. Patients with SLE (ACR 1997) consecutively seen at UNIFESP’s out patient’s clinics had disease activity measured after clinical and laboratory evaluation using SLEDAI (Systemic Lupus Erythematosus Dise...
Source: PLoS One - Category: Biomedical Science Authors: Source Type: research
Conclusions VDR FokI polymorphism in SLE patients is significantly related to low vitamin D level in SLE patients and both are associated with increasing disease activity and damage denoting important implications in this disease.
Source: The Egyptian Rheumatologist - Category: Rheumatology Source Type: research
We examined whether measures of vitamin D were associated with transitioning to systemic lupus erythematosus (SLE) in individuals at risk for SLE. Methods 436 individuals who reported having a relative with SLE but who did not have SLE themselves were evaluated at baseline and again an average of 6.3 (±3.9) years later. Fifty-six individuals transitioned to SLE (≥4 cumulative American College of Rheumatology criteria). 25-Hydroxyvitamin D (25[OH]D) levels were measured by ELISA. Six single-nucleotide polymorphisms in four vitamin D genes were genotyped. Generalised estimating equations, adjusting for correlation...
Source: Annals of the Rheumatic Diseases - Category: Rheumatology Authors: Tags: Genetics, Immunology (including allergy), Connective tissue disease, Systemic lupus erythematosus Clinical and epidemiological research Source Type: research
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