Low Vitamin D Worsens Lupus Risks in Kids (CME/CE)

(MedPage Today) -- Children with lupus commonly are vitamin D deficient, which may contribute to their heightened inflammatory status and cardiovascular risk, researchers reported.
Source: MedPage Today Pediatrics - Category: Pediatrics Source Type: news

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Conclusion: VitD serum values were lower in lupus patients than RA ones. Since VitD deficiency is very common in Iran, physiologic doses of VitD supplementation in patients lead to higher serum levels of VitD. Lower VitD values in lupus patients compared with RA ones may stem from intestinal malabsorption, higher doses of corticosteroid therapy, renal involvement and proteinuria, different polymorphisms of VitD receptors, and more sun protection strategies in lupus patients. PMID: 29854015 [PubMed]
Source: Open Rheumatology Journal - Category: Rheumatology Tags: Open Rheumatol J Source Type: research
Conclusion Serum vitamin D levels are inversely correlated with SLE disease activity at both active and inactive disease status, and also with the presence of LN at active disease stage.
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
ConclusionThis study suggests that cholecalciferol supplementation for 24  weeks effectively improved the bone microarchitecture parameters, mainly the trabecular number, in JoSLE patients.Trial RegistrationNCT01892748
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
This study aimed to evaluate the relationship between the level of 25-hydroxyvitamin D [25(OH)D] and systemic lupus erythematosus (SLE). We searched the PUBMED, EMBASE, and Cochrane databases and performed a meta-analysis examining the vitamin D level and/or deficiency in patients with SLE, compared with that in healthy controls. In total, 18 studies consisting of 1,083 patients with SLE and 1,273 controls were included. Vitamin D level was significantly lower in the SLE group than in the control group (standardized mean difference [SMD] = -0.938, 95% CI = -1.352 to -0.524, p = 9.0 × 10-6). Stratification by ethnicit...
Source: Cellular and Molecular Biology - Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research
Publication date: Available online 31 January 2018 Source:Autoimmunity Reviews Author(s): Stefano Stagi, Donato Rigante Systemic lupus erythematosus (SLE) and juvenile SLE (jSLE) are autoimmune disorders naturally associated with several genetic, environmental, hormonal, and immunological contributing factors. It has been assumed that vitamin D deficiency may have a role in the immune activation of patients with SLE and play an active part in many comorbidities and even complications. A host of clinical studies suggested that vitamin D exerts inhibitory effects on many immunological abnormalities associated with SLE, also...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
In conclusion, no factor of the epidemiologic triad was associated with HPV infection prevalence. PMID: 29732937 [PubMed - as supplied by publisher]
Source: Lupus - Category: Rheumatology Authors: Tags: Lupus Source Type: research
AbstractVitamin D is one of the main groups of sterols; playing an important role in phospho-calcic metabolism. The conversion of 7-dehydrocholesterol to pre- vitamin D3 in the skin, through solar ultraviolet B radiation, is the main source of vitamin D. Since lupus patients are usually photosensitive, the risk of developing vitamin D deficiency in is high in this population. Although evidences showed the connotation between systemic lupus erythematosus (SLE) and vitamin D through which SLE can lead to lower vitamin D levels, it is also important to consider the possibility that vitamin D deficiency may have a causative ro...
Source: Autoimmunity Highlights - Category: Allergy & Immunology Source Type: research
This study aimed to perform a systematic review and meta-analysis on the association between vitamin D levels and AA.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Tags: Research letter Source Type: research
A new study examines the role of vitamin D deficiency in the organ inflammation and damage that occurs in systemic lupus erythematosus.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Lupus Source Type: news
Publication date: Available online 3 November 2017 Source:Autoimmunity Reviews Author(s): Yehuda Shoenfeld, Roberto Giacomelli, Shir Azrielant, Onorina Berardicurti, John A. Reynolds, Ian N. Bruce Over the past 20years, much has been written about the potential role of vitamin D in on adverse health outcomes. In recent years, evidence has accumulated regarding the effect of vitamin D on the immune system, and its different cells. Some studies have noted lower vitamin D concentrations in patients with SLE. These epidemiological data still not answer the question: is vitamin D deficiency the cause or the effect? To answer t...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
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