Switch Rates During Acute Treatment for Bipolar II Depression With Lithium, Sertraline, or the Two Combined: A Randomized Double-Blind Comparison.

CONCLUSIONS: Lithium monotherapy, sertraline monotherapy, and lithium/sertraline combination therapy were associated with similar switch and treatment response rates in participants with bipolar II depression. The dropout rate was higher in the lithium/sertraline combination treatment group, without any treatment acceleration advantage.
PMID: 28135846 [PubMed - as supplied by publisher]

Source: The American Journal of Psychiatry - January 30, 2017 Category: Psychiatry Authors: Altshuler LL, Sugar CA, McElroy SL, Calimlim B, Gitlin M, Keck PE, Aquino-Elias A, Martens BE, Fischer EG, English TL, Roach J, Suppes T Tags: Am J Psychiatry Source Type: research