Sex-Specific Effects of Organophosphate Diazinon on the Gut Microbiome and Its Metabolic Functions

Conclusions: Diazinon exposure perturbed the gut microbiome community structure, functional metagenome, and associated metabolic profiles in a sex-specific manner. These findings may provide novel insights regarding perturbations of the gut microbiome and its functions as a potential new mechanism contributing to diazinon neurotoxicity and, in particular, its sex-selective effects. Citation: Gao B, Bian X, Mahbub R, Lu K. 2017. Sex-specific effects of organophosphate diazinon on the gut microbiome and its metabolic functions. Environ Health Perspect 125:198–206; http://dx.doi.org/10.1289/EHP202 Address correspondence to K. Lu, 140 Environmental Health Science Building, University of Georgia, Athens, GA 30602 USA. Telephone: (706) 542-1001. E-mail: kunlu@uga.edu National Institutes of Health grant ES024950 and UGA (University of Georgia) Startup grants provided partial financial support for this work. The authors declare they have no actual or potential competing financial interests. Received: 8 July 2015 Revised: 27 October 2015 Accepted: 18 April 2016 Published: 20 May 2016 Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our s...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Articles February 2017 Source Type: research

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