Folliculocentric Herpes: A Clinicopathological Study of 28 Patients
Conclusions: Cutaneous herpetic eruptions can evoke a predominantly folliculocentric mononuclear cell reaction and vasculitis; there is an association with underlying endogenous and/or iatrogenic immune dysregulation. Most cases are secondary to reactivation of varicella zoster. The histomorphology suggests a role for cell-mediated immunity. Antigenic homology of an endogenous 72-kd heat shock protein in follicles with that of a herpetic heat shock protein, in concert with an intrafollicular proliferative response of γ-δ T lymphocytes, may explain the follicular localization and composition of the infiltrate.
Source: The American Journal of Dermatopathology - Category: Pathology Tags: Original Study Source Type: research
More News: Cancer & Oncology | Crohn's Disease | Dermatitis | Dermatology | Diabetes | Diabetes Mellitus | Endocrinology | Herpes | Hidradenitis | Inflammatory Bowel Disease | Psoriasis | Skin | Skin Biopsy | Study | Vasculitis | Women