Epidemiology and pharmacoepidemiology of immune thrombocytopenia.

[Epidemiology and pharmacoepidemiology of immune thrombocytopenia]. Rev Med Interne. 2017 Jan 25;: Authors: Moulis G, Lapeyre-Mestre M, Adoue D, Sailler L Abstract During the last decade, the development of large clinical and population-based cohorts led to new findings in the epidemiology and the pharmacoepidemiology of immune thrombocytopenia (ITP). The incidence is estimated to 3-4 for 10(5) inhabitants/year, with a slight female predominance and peaks in children and patients after 60 years. The incidence rate is 9 for 10(5) inhabitants/year in males after 75 years. Variations across ethnic groups are discussed. In France, there is a North-South gradient and a peak of incidence during winter suggesting the role of viruses in ITP pathophysiology. Myelodysplastic syndromes are an emergent cause of secondary ITP. The incidence of intracranial bleeding is about 1% by year and the risk increases with aging. Exposure to splenectomy decreases while rituximab and thrombopoietin receptor agonists (TPO-RA) are the most used second-line drugs for persistent ITP. Mortality is slightly increased in primary ITP as compared with the general population. ITP patients have an increased risk of infection, thrombosis and hemorrhage. Aging, lung diseases, splenectomy, corticosteroids and rituximab are risk factors for infection while influenza and pneumococcal vaccines are associated with a 50% decrease of infection risk. Aging, cardiovascular risk fac...
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research

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Publication date: November 2018Source: Biomedicine &Pharmacotherapy, Volume 107Author(s): Ming-Yue Zhang, Jie-Bing Wang, Zhi-Wei Zhu, Lian-Ju Li, Rui-Shan Liu, Xiao-Ke Yang, Rui-Xue Leng, Xiao-Mei Li, Hai-Feng Pan, Dong-Qing YeAbstractIt has been reported that circRNAs are diff ;erentially expressed in many diseases and can be used as new biomarker to facilitate disease diagnosis. Circular RNAs (circRNAs) microarray were used to identify dysregulated circRNAs in plasma of systemic lupus erythematosus (SLE) patients. Then, we confirmed the microarray data by quantitative reverse transcription polymerase chain reaction ...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Julie Westerlin Kjeldsen, Trine Zeeberg Iversen, Lotte Engell-Noerregaard, Anders Mellemgaard, Mads Hald Andersen, Inge Marie Svane
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
In this study, we investigated the CSC targeting effect of the CSC-DC vaccine combined with a dual blockade of programmed death-ligand 1 and cytotoxic T-lymphocyte-associated protein (CTLA-4) in B16-F10 murine melanoma tumor model. Our data showed that animals treated with the dual blockade of programmed death-ligand 1 and CTLA-4 and CSC-DC vaccine conferred significantly more tumor regression than the CSC-DC vaccine alone. Importantly, the triple combination treatment dramatically eliminated ALDHhigh CSCs in vivo. We observed that CSC-DC vaccine in combination with anti-PD-L1 and anti-CTLA-4 administration resulted in &si...
Source: Journal of Immunotherapy - Category: Allergy & Immunology Tags: Basic Studies Source Type: research
Authors: Chakraborty A, Boer JC, Selomulya C, Plebanski M, Royce SG Abstract INTRODUCTION: Airway inflammatory disorders are prevalent diseases in need of better management and new therapeutics. Immunotherapies offer a solution to the problem of corticosteroid resistance. Areas covered: The current review focuses on lipopolysaccharide (Gram-negative bacterial endotoxin)- mediated inflammation in the lung and the animal models used to study related diseases. Endotoxin-induced lung pathology is usually initiated by antigen presenting cells (APC). We will discuss different subsets of APC including lung dendritic cells...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
In this study, the authors utilized the IMPROVE bleeding definition to explore the safety profile of pharmacologic VTE prophylaxis in patients with CLD and concurrent coagulopathy (INR≥ 1.5). METHODS: A retrospective study was conducted on 193 adult patient admissions with a diagnosis of CLD and INR ≥1.5 not due to therapeutic anticoagulation. Patients were stratified based on their receipt of pharmacological thromboprophylaxis or not during hospitalization. The rates of overall bleeding defined as the composite of major bleeding and clinically relevant non-major bleeding; major bleeding and; clinically relevant ...
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
Conclusion: Norepinephrine release induced by SAH and/or iatrogenic administration of norepinephrine may have promoted abdominal SAM in this case. Abdominal SAM may occur subsequent to rupture of ordinary saccular aneurysm, and may provoke catastrophic abdominal hemorrhage in the spasm stage after SAH. PMID: 30221020 [PubMed]
Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
GP practices can administer the quadrivalent (QIV) flu vaccine to patients over 65 as a'last resort' and still be reimbursed in the usual way, the BMA has said. Hide related content:  Show related contentread more
Source: Management in Practice - Category: Practice Management Authors: Tags: *** Editor ' s Pick Patients Practice management Latest News Source Type: news
FLU jab is available every year on the NHS but also from pharmacies and supermarkets. It ’s the recommended form of protection against the virus, but can the flu jab make you ill after having it? Some symptoms and side effects can occur.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
MALARIA is currently plaguing the Indonesian tourist island of Lombok, where a recent earthquake devastated the country, paving the way for a potentially deadly Malaria outbreak. Is there a vaccine for Malaria?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Authors: Abizaid A, Kedev S, Kedhi E, Talwar S, Erglis A, Hlinomaz O, Masotti M, Fath-Ordoubadi F, Lemos PA, Milewski K, Botelho R, Costa R, Bangalore S Abstract AIMS: To evaluate the safety and efficacy of BioMime™ sirolimus-eluting coronary stent (SES) compared to the XIENCE family everolimus-eluting coronary stent (EES) in the treatment of patients with de novo native coronary artery lesions. METHODS AND RESULTS: The meriT-V is a prospective, multicenter, randomized, open-label, active-controlled, and non-inferiority trial. A total of 256 patients with up to two de novo native coronary artery lesions w...
Source: EuroIntervention - Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research
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