The Insect repellents: A silent environmental chemical toxicant to the health

Publication date: Available online 29 January 2017 Source:Environmental Toxicology and Pharmacology Author(s): Dijendra Nath Roy, Ritobrata Goswami, Ayantika Pal In recent years, a large number of insect repellents have been developed with the idea of consumer benefits. In addition to already known advantageous application of insect repellents, there is increasing concern about the potential toxicity in environment leading to health caused by random use of these compounds. An increasing number of evidence suggests that insect repellents may trigger undesirable hazardous interactions with biological systems with a potential to generate harmful effects including intermediate metabolites. Biotransformation followed by bioaccumulation (vice e versa) may be an important phenomenon for toxic response of this chemicals. In this review, we have summarized the current state of knowledge on the insect repellent toxicity, including biochemical pathway alteration under in vitro and in vivo conditions considering different classes of organisms, from lower to higher vertebrate. Furthermore, we have tried to incorporate the effects of insect repellent in light of some clinical reports. We hope this review would provide useful information on potential side effects of uncontrolled use of insect repellents.
Source: Environmental Toxicology and Pharmacology - Category: Environmental Health Source Type: research

Related Links:

ConclusionThere is a need to intensify efforts at public education in relation to disability acceptance as well as to develop formidable social support systems.
Source: Research in Developmental Disabilities - Category: Disability Source Type: research
Publication date: Available online 14 November 2019Source: NeuronAuthor(s): Max E. Joffe, Chiaki I. Santiago, Kendra H. Oliver, James Maksymetz, Nicholas A. Harris, Julie L. Engers, Craig W. Lindsley, Danny G. Winder, P. Jeffrey ConnSummaryNon-selective antagonists of metabotropic glutamate receptor subtypes 2 (mGlu2) and 3 (mGlu3) exert rapid antidepressant-like effects by enhancing prefrontal cortex (PFC) glutamate transmission; however, the receptor subtype contributions and underlying mechanisms remain unclear. Here, we leveraged newly developed negative allosteric modulators (NAMs), transgenic mice, and viral-assisted...
Source: Neuron - Category: Neuroscience Source Type: research
AbstractThe development of Alzheimer's disease (AD) has been strongly linked to the apolipoprotein E (APOE) polymorphism. A number studies have reported that theAPOEε4 allele is a genetic risk factor for developing AD, whereas theAPOEε2 andAPOEε3 alleles are considered to be neutral or even protective; however, there are conflicting data about these relationships in certain ethnic populations. Several meta-analyses have been performed to reduce the heterogeneity of results from different studies and estimate the real association in speci fic ethnicities. The aim of this study was to investigate the ...
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research
Authors: Ariceta G, Buj MJ, Furlano M, Martínez V, Matamala A, Morales M, Robles NR, Sans L, Villacampa F, Torra R Abstract Tuberous sclerosis complex (TSC) is a rare, hereditary, multisystemic disease with a broad phenotypic spectrum. Its management requires the collaboration of multiple specialists. Just as in the paediatric age, the paediatric neurologist takes on special importance; in adulthood, renal involvement is the cause of the greatest morbidity and mortality. There are several recommendations on the general management of patients with TSC but none that focuses on renal involvement. These recommen...
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - Category: Urology & Nephrology Tags: Nefrologia Source Type: research
Spinal Oncology
Source: Neurosurgery Clinics of North America - Category: Neurosurgery Source Type: research
Nathaniel P. Brooks and Michael Y. Wang
Source: Neurosurgery Clinics of North America - Category: Neurosurgery Source Type: research
RUSSELL R. LONSER, MD
Source: Neurosurgery Clinics of North America - Category: Neurosurgery Source Type: research
ELSEVIER
Source: Neurosurgery Clinics of North America - Category: Neurosurgery Source Type: research
NEUROSURGERY CLINICS OF NORTH AMERICA
Source: Neurosurgery Clinics of North America - Category: Neurosurgery Authors: Source Type: research
This article provides an evidence-based personal perspective on the future of cell and gene therapy for degenerative diseases of the intervertebral disc. This paper focuses on how mammalian protein production platforms and transfected and irradiated protein packaging cell lines may be used as “cellular factories” for overproduction of therapeutic proteins and proanabolic growth factors, particularly in the context of regenerative therapies. This paper also speculates on future opportunities and challenges in this area of research and how new innovations in biotechnology affect cell a nd gene therapy for degenerative diseases.
Source: Neurosurgery Clinics of North America - Category: Neurosurgery Authors: Source Type: research
More News: Chemistry | Drugs & Pharmacology | Environmental Health | Toxicology