The Microenvironment Matters: Estrogen Deficiency Fuels Cancer Bone Metastases.

The Microenvironment Matters: Estrogen Deficiency Fuels Cancer Bone Metastases.
Clin Cancer Res. 2014 May 6;
Authors: Wright LE, Guise TA
Abstract
Factors released during osteoclastic bone resorption enhance disseminated breast cancer cell progression by stimulating invasiveness, growth, and a bone-resorptive phenotype in cancer cells. Postmenopausal bone loss may accelerate progression of breast cancer growth in bone, explaining the anticancer benefit of the bone-specific antiresorptive agent zoledronic acid in the postmenopausal setting. Clin Cancer Res; 20(11); 1-3. ©2014 AACR.
PMID: 24803577 [PubMed - as supplied by publisher]

Source: Clinical Breast Cancer - May 6, 2014 Category: Cancer & Oncology Authors: Wright LE, Guise TA Tags: Clin Cancer Res Source Type: research