Socioeconomic Inequalities and Severity of Plaque Psoriasis at a First Consultation in Dermatology Centers.
Socioeconomic Inequalities and Severity of Plaque Psoriasis at a First Consultation in Dermatology Centers. Acta Derm Venereol. 2017 Jan 27;: Authors: Mahé E, Beauchet A, Reguiai Z, Maccari F, Ruer-Mulard M, Chaby G, Guyadec TL, Estève E, Goujon-Henry C, Parier J, Barthelemy H, Bégon E, Steiner HG, Bénéton N, Boyé T, Mery-Bossard L, Schmutz JL, Bravard P, Resopso MS Abstract Psoriasis has major physical, psychological, and social impacts: its management should not be restricted by individual financial considerations in Western countries as these have well-structured health systems and social/insurance coverage. We investigated if the socioeconomic characteristics of patients were associated with severity of psoriasis and access to healthcare. In a cross-sectional study, we included 903 patients with psoriasis that were consulting for the first time. We showed that low educational level was associated with severity of disease in multivariate analyses. Moreover, patients of lower class and lower educational level, with severe psoriasis, had seen fewer physicians and had less frequently received a systemic treatment. Thus, physicians need to be vigilante of patients with a low socioeconomic status. Both low socioeconomic status and less access to dermatologists are associated with clinical severity of psoriasis at a first consultation. PMID: 28127620 [PubMed - as supplied by publisher]
AbstractPurpose of ReviewAnkylosing spondyloarthritis (AS) is a chronic inflammatory disease that involves the axial joints and entheses. Extra-spinal manifestations such as anterior uveitis, psoriasis, and colitis also occur frequently. This review on the pathogenesis of AS includes an update on the recent discoveries within the field.Recent FindingsHLA-B*27 is still considered of major importance in the pathogenesis, and it has recently been shown to profoundly affect the gut microbiome and its metabolites and the handling of bacteria during infection. Biochemical and biophysical properties of HLA-B*27 influence its abil...
Publication date: Available online 9 November 2019Source: International Journal of PharmaceuticsAuthor(s): Sindhu Doppalapudi, Anjali Jain, Wahid Khan, Abraham J. DombAbstractFenoldopam, a highly selective dopamine receptor agonist, is available in clinics as Corlopam™ i.v. for the management of severe hypertension. Recent reports demonstrate its anti-proliferative activity in vitro in a dose dependent manner. However, stability issues of the drug due to its susceptibility to oxidation, pH sensitivity, poor transdermal flux, and the barrier properties of skin present challenges to develop a topical formulation of fen...
Authors: El Jammal T, Gerfaud-Valentin M, Sève P, Jamilloux Y Abstract In the past ten years, the better understanding of the pathophysiological mechanisms underlying inflammatory and autoimmune diseases has led to the emergence of many targeted therapies. Among them, the Janus kinase inhibitors are acting upstream in the inflammatory cascade of several key cytokines in disorders such as rheumatoid arthritis, ulcerative colitis or psoriasis. At the moment, these three diseases represent the only indications validated by the FDA and the EMA of the use of JAK inhibitors apart from hematology. Preclinical data ...
Treatment of anti-TNF-related paradoxic palmoplantar psoriasis in Behçet's disease with azathioprine. Clin Exp Rheumatol. 2019 Oct 17; Authors: Karadeniz H, Ataş N, Avanoğlu Güler A, Tufan A PMID: 31694755 [PubMed - as supplied by publisher]
Conclusions: This review highlights the research in support of common treatments of GPP, including classically used medications and newer monoclonal antibodies, and addresses the continued need for high quality studies regarding treatments for this condition. PMID: 31697211 [PubMed - as supplied by publisher]
Conclusion: CBT as an adjunct to conventional dermatological treatments may be particularly beneficial for individuals with more severe pretreatment psychopathology in improving psoriasis severity, anxiety, and depression symptoms. CBT appears to be generally effective in improving quality of life. Greater methodological rigour is needed in future research. PMID: 31696748 [PubMed - as supplied by publisher]
CONCLUSION: IFX Cmin significantly influences PASI 90/100 response rates. IFX Cmin were significantly associated with ATI and BMI. The observed inter-individual variability in IFX Cmin supports the need for IFX drug monitoring. PMID: 31696747 [PubMed - as supplied by publisher]
Conclusion: Most (87.4%) ixekizumab users remained persistent during follow-up. Pharmacy was the primary driver of total healthcare costs, with the majority covered by health plans and
Conclusions: Psoriasis education by HCP seems important for HL and psoriasis knowledge. Patients may need multiple approaches and repetitions over time to be health literate and effective self-managers. PMID: 31692398 [PubMed - as supplied by publisher]
Authors: Chat VS, Kearns DG, Uppal SK, Wu JJ PMID: 31689137 [PubMed - as supplied by publisher]