An outbreak inside an epidemic: managing an infectious disease outbreak while treating Ebola

Even in the middle of an epidemic of a very serious illness, outbreaks of other infectious diseases will continue. Clinicians need to be able to make rapid decisions about the nature of the outbreak and how to manage it. A balance needs to be struck between managing all patients as if they have the worst-case scenario illness and the resultant risks to themselves, their colleagues and the mission. This paper reviews basic epidemiological tools that inform robust decision-making in the management of such outbreaks. It then describes how a pragmatic approach, combined with effective use of these techniques, rapid diagnostics and remote specialist support, allowed a large outbreak of gastroenteritis to be safely and effectively managed during the response to the Ebola virus disease epidemic in Sierra Leone.
Source: Journal of the Royal Army Medical Corps - Category: Journals (General) Authors: Tags: Drugs: gastrointestinal system, Infection (gastroenterology), Infectious diseases Review Source Type: research

Related Links:

This article reports the characterization and evaluation of the biotechnological potential of a cysteine protease purified from Calotropis procera (CpCP3). This enzyme was highly stable to different metal ions and was able to hydrolyze κ-casein similarly to bovine chymosin. Atomic force microscopy showed that the process of casein micelle aggregation induced by CpCP3 was similar to that caused by chymosin. The cheeses made using CpCP3 showed higher moisture content than those made with chymosin, but protein, fat, and ash were similar. The sensory analysis showed that cheeses made with CpCP3 had high acceptance index ...
Source: Food Chemistry - Category: Food Science Source Type: research
Publication date: Available online 13 October 2019Source: Redox BiologyAuthor(s): Kaibo Xie, Marharyta Varatnitskaya, Abdelouahid Maghnouj, Verian Bader, Konstanze F. Winklhofer, Stephan Hahn, Lars I. LeichertAbstractNeutrophils produce a cocktail of oxidative species during the so-called oxidative burst to attack phagocytized bacteria. However, little is known about the neutrophils' redox homeostasis during the oxidative burst and there is currently no consensus about the interplay between oxidative species and cellular signaling, e.g. during the initiation of the production of neutrophil extracellular traps (NETs). Using...
Source: Redox Biology - Category: Biology Source Type: research
According to a new publication by the Council for Agricultural Science and Technology (CAST), the genetic diversity of livestock and poultry is declining, leaving one-third of the world’s protein supply at risk to extreme weather and disease outbreaks. CAST warns that “up to 25 percent of global livestock breeds are either at risk of being lost, or have already been lost.” The report discusses the risks associated with reduced access to genetic traits and recommends actions to protect remaining breeds that build on current conservation practices such as cryopreservation and germplasm repositories. &ldqu...
Source: Public Policy Reports - Category: Biology Authors: Source Type: news
In this study, partially substituted analog D-Arg-W3R6 and completely substituted D-enantiomer D-W3R6 were synthesized. The resistance of D-Arg-W3R6 and D-W3R6 to cleavage by the tested protease increased, particularly of D-W3R6. The antimicrobial activity of D-Arg-W3R6 was almost the same as that of the parent peptide W3R6, but the antimicrobial activity of D-W3R6 was slightly decreased. The hemolytic activity of both D-Arg-W3R6 and D-W3R6 was negligible. The CD spectrum of D-W3R6 exhibited symmetry with that of W3R6 in a membrane-mimetic environment. The membrane interaction between the D-amino acid substituted analogs a...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
[Vanguard] Health authorities in the Democratic Republic of Congo will introduce a Johnson&Johnson Ebola vaccine in November in the country's eastern provinces, to counter the current outbreak, they said.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
We are once again at the start of a workweek. So I thought this would be a good time to share 87 of the most inspirational work quotes. Quotes that will motivate you, help you to focus and work smarter and also reduce the stress and pressure you may feel at work (or in school). These quotes have helped me many times to re-ignite my own motivation on a rough or bad day and to find a calmer and less stressed focus so I could keep working consistently towards my own goals and dreams. I hope they will help you to do the same. Motivational Quotes for Work “Concentrate all your thoughts upon the work in hand. The sun's ra...
Source: Practical Happiness and Awesomeness Advice That Works | The Positivity Blog - Category: Consumer Health News Authors: Tags: Personal Development Source Type: blogs
[Observer] -- Stakeholders grade project successful
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Did the movie Joker portray mental illness correctly and does it matter? We passionately go over the movie Joker from the lense of people living with mental illness and discuss whether or not there are implications of making a movie like this. Does it help us or hurt us? What if it does both? Listen in to hear Gabe’s freakishly good recollection of scenes from the movie as Jackie struggles to separate entertainment from reality.  Spoiler Alert: You don’t need to see Joker to appreciate this conversation but we do go over the plot and reveal some important scenes from the movie. (Transcript Available Below)...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: A Bipolar, A Schizophrenic, and a Podcast Antidepressant Antipsychotic Depression Minding the Media Not Crazy Podcast Source Type: blogs
Pig skin isn ’t just for football these days.  Massachusetts General Hospital surgeons have successfully used genetically engineered pig skin for the temporary closure of a burn wound, the first time pig tissue derived from an animal with gene edits has been transplanted directly onto a human wound.  The F DA-cleared phase one clinical trial was led by surgeon Dr. Jeremy Goverman of MGH's Sumner Redstone Burn Center.  “It is not the trial itself that is so mind-boggling and intriguing to…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
China's pig herd in September was 41.1% smaller than it was a year earlier, the agriculture ministry said on Monday, as a year-long African swine fever epidemic continued to slash the world's largest herd.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
More News: Burns | Ebola | Epidemics | Epidemiology | Gastroenteritis | Gastroenterology | General Medicine | Infectious Diseases | Outbreaks