Cognitive decline and dementia in Down syndrome

Purpose of review: Alzheimer's disease is most likely universal in older individuals with Down syndrome, due to having three copies of the amyloid precursor protein gene, resulting in amyloid-beta plaque deposition. Down syndrome is an important population in which to consider clinical trials of treatments to prevent or delay the development of dementia. However, assessment of subtler cognitive changes is challenging due to the presence of intellectual disability. Recent findings: Recent research confirmed that older adults with Down syndrome often present with cognitive decline: more than 80% may experience dementia by age 65 years. Efforts have been made to improve and validate neuropsychological assessment and to describe the relationship with comorbidities such as epilepsy and haemorrhagic stroke. There have also been advances in biomarkers such as neuroimaging using amyloid PET. Summary: Clinical trials of treatments, particularly in the presymptomatic phase of Alzheimer's disease, are important to consider in individuals with Down syndrome given their high dementia burden, and may also serve as proof of concept for other forms of Alzheimer's disease. However, further work is required to improve outcome measures and better understand the biomarkers of progression of disorder and their relationship with symptom development during the presymptomatic period.
Source: Current Opinion in Psychiatry - Category: Psychiatry Tags: NEURODEVELOPMENTAL DISORDERS: Edited by James C. Harris Source Type: research

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Source: Neural Plasticity - Category: Neurology Authors: Tags: Neural Plast Source Type: research
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Source: Life Sciences - Category: Biology Source Type: research
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Source: Regional Science and Urban Economics - Category: Science Source Type: research
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Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
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Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
In conclusion, about one-third of the patients with AF did not regularly see a doctor in a medical institution and most of them had a CHADS2 score of more than one point in a Japanese rural area. Educating the public about the risks of AF is required. PMID: 31735770 [PubMed - as supplied by publisher]
Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
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Source: Quality of Life Research - Category: Health Management Source Type: research
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Source: Geburtshilfe und Frauenheilkunde - Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Research Methods, Surveillance and Codes, Models Source Type: news
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Risk Factor Prevalence, Injury Occurrence Source Type: news
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