Lab notes: It's life, Jim, but not as we know it

Things took a turn for the mythological this week with the creation ofa human-pig hybrid, or chimera. It marks the first time that embryos combining two large, distantly-related species have been produced and is a big step towards being able to generate human hearts, livers and kidneys for transplant. And as if pig-humans (or human-pigs, or ... whatever) weren ’t enough, researchers havemodifiedE coli microbes to carry an expanded genetic code. Apparently this will ultimately allow them to be programmed, but also paves the way for the creation and exploitation of entirely new life forms. Given that human interactions with other species tend togo the way of the Cern weasel, this might not be great for whatever emerges, but still. Yay science. Definitely good news for everyone is the possibility that a radical therapy involving the tranquiliserketamine could treat alcohol addiction by “erasing” drink-related memories. It’s extremely exciting that we’re starting to unpick how drugs interact with the brain. Another study this week, into LSD, has revealedwhy acid trips last so long– adding to our understanding of the brain’s serotonin receptors. Perhaps the only piece of science news this week that didn’t add to our understanding was the furore over the “dangers” of roast potatoes and burnt toast. Time toread some actual facts about acrylamide and ponder our ownreactions to “scientific” pronouncements.Continue...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Science Source Type: news

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Research ArticlesS. ROWELL, C. KING, C. JENKINS, T. J. DALLMAN, V. DECRAENE, K. LAMDEN, A. HOWARD, C. A. FEATHERSTONE, P. CLEARY,Epidemiology&Infection,Volume 144 Issue 12, pp 2494-2500Abstract
Source: Epidemiology and Infection - Category: Epidemiology Source Type: research
Research ArticlesM. DAS GUPTA, A. DAS, M. Z. ISLAM, P. K. BISWAS,Epidemiology&Infection,Volume 144 Issue 12, pp 2501-2508Abstract
Source: Epidemiology and Infection - Category: Epidemiology Source Type: research
Research ArticlesNoah D. Silverberg, William Panenka, Grant L. Iverson, Jeffrey R. Brubacher, Jason R. Shewchuk, Manraj K.S. Heran, Gary C.S. Oh, William G. Honer, Rael T. LangeJournal of the International Neuropsychological Society,FirstView Article(s), 12 pagesAbstract
Source: Journal of the International Neuropsychological Society - Category: Neurology Source Type: research
Research ArticlesShin Narita, Kenta Nagahori, Daisuke Nishizawa, Eiji Yoshihara, Atsuko Kawai, Kazutaka Ikeda, Kazuhiko Iwahashi,Acta Neuropsychiatrica,Volume 28 Issue 04, pp 214-220Abstract
Source: Acta Neuropsychiatrica - Category: Neurology Source Type: research
ConclusionThe prevalence of non-adherence was 16.5%. Determinants of non-adherence were Deceased Donor Liver Transplant, belief in alternative medications, high regimen complexity, poor knowledge about medications and cost issues with long term medications.
Source: Journal of Clinical and Experimental Hepatology - Category: Gastroenterology Source Type: research
This article reviews the treatment advances in DLBCL with novel and targeted agents that are aimed to improve efficacy especially in those with high-risk features. Expert opinion: Incorporation of novel therapies such as immunomodulatory agents and Bruton tyrosine kinase (BTK) inhibitors in treatment of higher-risk DLBCL subgroups have shown to be effective, however, confirmatory data are required to change the standard of care. While, autologous chimeric antigen receptor (CAR) T-cell therapy targeting CD19-positive B-cells have revolutionized the outcomes of refractory DLBCL, the complexity of its production, post-infusio...
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research
(Wiley) In an Addiction analysis of relevant published studies, investigators found some evidence for a positive association between anxiety during childhood and adolescence with later alcohol use disorders.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
(Wiley) Several previous studies have demonstrated that moderate alcohol consumption is linked with less severe disease and better quality of life in patients with rheumatoid arthritis, but a new Arthritis Care&Research study suggests that this might not be because drinking alcohol is beneficial.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Contributors : Ines Ambite ; Jenny Gr önberg-Hernández ; Bela Köves ; Björn Wullt ; Catharina SvanborgSeries Type : Expression profiling by arrayOrganism :Mucosal surfaces provide ideal living conditions for the normal flora but paradoxically, they also serve as attack sites for numerous bacterial pathogens that cause extensive morbidity and mortality. Understanding this dichotomy is critical for efforts to selectively target and remove pathogens without disturbing the commensal flora or its protective effects. The complex nature of disease predicts that virulence is multifaceted and that pathogens ne...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Source Type: research
Contributors : Lynn Yap ; Aida Moreno-Moral ; Enrico Petretto ; Karl TryggvasonSeries Type : Expression profiling by high throughput sequencingOrganism :Regeneration of injured human heart muscle is limited and an unmet clinical need. There are no methods for the reproducible generation of clinical quality stem-cell-derived cardiovascular progenitors (CVPs). We identified laminin-221 (LN-221) as the most likely expressed cardiac laminin. We produced it as human recombinant protein, and showed that LN-221 promotes differentiation of pluripotent hESCs towards cardiomyocyte lineage and downregulates pluripotency and teratoma ...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Source Type: research
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