Efficacy of Administration of ACE-Inhibition on Autonomic and Peripheral Neuropathy in Patients With Diabetes Mellitus

Condition:   Diabetic Autonomic Neuropathy Intervention:   Drug: Quinapril Sponsor:   Aristotle University Of Thessaloniki Completed - verified January 2017
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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HbA1c variability has been linked to retinopathy, renal disease and autonomic neuropathy in patients with type 1 diabetes mellitus (T1D) and type 2 diabetes mellitus (T2D). Although the same relationship has b...
Source: Diabetology and Metabolic Syndrome - Category: Endocrinology Authors: Tags: Short report Source Type: research
The prevalence of type 2 diabetes mellitus (T2DM) in aging adults in the U.S. has risen dramatically, particularly among U.S. Veterans, where it currently affects over 20% of the Veteran population [1]. Metformin is recommended as a first line treatment for individuals with T2DM and normal kidney function, resulting in nearly 70% of all U.S. Veterans receiving metformin to treat their T2DM [2].
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
This study provides a possible therapeutic strategy for DPN. PMID: 32996080 [PubMed - as supplied by publisher]
Source: Molecular and Cellular Biochemistry - Category: Biochemistry Authors: Tags: Mol Cell Biochem Source Type: research
The early pathological changes of diabetic peripheral neuropathy are mainly small nerve fiber injuries. Corneal confocal microscopy is a simple, non ‐invasive and repeatable technique to detect the damage of small nerve fibers. The purpose of this study was to explore the application of corneal confocal microscopy in diabetic peripheral neuropathy and other chronic complications of type 2 diabetes mellitus. AbstractAims/IntroductionThe early pathological changes of diabetic peripheral neuropathy (DPN) are mainly small nerve fiber injuries. Corneal confocal microscopy (CCM) is an easy, rapid, non ‐invasive and repe...
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: Original Article Source Type: research
Abstract Peripheral neuropathy is a disorder of the peripheral nerves and results from a disturbance of structure and/or function of the peripheral sensory, motor and/or autonomic neurons. The possible aetiology of peripheral neuropathies is diverse, but inflammatory and hereditary diseases of the peripheral nerves predominate in childhood. The aim of this study was to determine the clinical and electrophysiological profile of large nerve fibre neuropathy detected by nerve conduction studies (NCS) in children over a 10-year period at the Children's Clinical University Hospital in Latvia. Based on NCS findings, 165...
Source: Neurologia i Neurochirurgia Polska - Category: Neurology Authors: Tags: Neurol Neurochir Pol Source Type: research
This study aimed to evaluate its preventive and therapeutic effects on DPN in rats with streptozotocin (STZ)-induced diabetes and explore the underlying mechanisms. In vitro, RSC96 cells were exposed to high glucose (100 mM) and then treated with different concentrations of DPDs (1, 10, 25 and 50 μM). Notably, DPDs markedly suppressed high glucose-induced cytotoxicity and oxidative stress in Schwann cells by decreasing reactive oxygen species (ROS) and malondialdehyde (MDA) levels. Furthermore, the DPDs treatment effectively activated Nrf2 signaling and inhibited Keap1 expression. An in vivo DPN model was established in...
Source: Biochemical Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Biochem Pharmacol Source Type: research
Diabetes mellitus (DM) is a physiological disorder provoked by endogenous insulin deficiency and impaired insulin efficiency, or both. It is characterised by hyperglycaemia and is associated with chronic complications that can affect nearly all organs in the body [1]. According to the International Diabetes Federation, 425 million people worldwide, or 8.8% of adults aged 20 –79 years, had DM in 2017, four times more than in 1980. This figure is expected to increase to 642 million by 2040 [2].
Source: Primary Care Diabetes - Category: Primary Care Authors: Tags: Original research Source Type: research
Authors: Abelleira R, Zamarrón C, Ruano A, Lourido T, Rodríguez-Núñez N, González-Barcala FJ, Toubes ME, Álvarez-Dobaño JM, Ricoy J, Valdés L Abstract INTRODUCTION: Diabetes mellitus and sleep apnoea-hypopnoea syndrome appear to be related, but it is not well defined whether there is an increased risk of peripheral neuropathy in patients with both diseases. For this reason, we conducted a systematic review. METHODS: Bibliographic search in 3 electronic databases using a predefined strategy and the PRISMA methodology. Only original studies (any type of desi...
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
ConclusionHere, we found for the first time that GJG improves the mechanical hypoesthesia in the later stage of DPN.
Source: Traditional and Kampo Medicine - Category: Complementary Medicine Authors: Tags: ORIGINAL ARTICLE Source Type: research
Diabetic foot is one of the dreaded complications of diabetes mellitus (DM). Alterations of the Achilles tendon (AT) may contribute to development of foot ulcers in diabetic patients. We evaluated the sonoelastographic abnormalities of the AT in 61 healthy volunteers and 81 patients with type 2 DM. The patients were further divided into those with and without peripheral neuropathy (PN). The AT thickness was measured in the proximal, middle and distal portions. Alterations in echo pattern were noted.
Source: Ultrasound in Medicine and Biology - Category: Radiology Authors: Tags: Original Contribution Source Type: research
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