Theravance reports positive Phase II trial results of fibromyalgia drug candidate

US-based biopharmaceutical firm Theravance has revealed positive results from a Phase II trial of its investigational norepinephrine and serotonin reuptake inhibitor (NSRI) 'TD-9855' in patients with fibromyalgia (FM).
Source: Drug Development Technology - Category: Pharmaceuticals Source Type: news

Related Links:

You're reading A Physician Letter Essay Sample, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. From: Dr. Abu Salim Idris (Consultant Neurologist at KPJ Tawakkal Hospital/ MMC NO 23250 / nsr 124687/) To: Whom it may concern I Am writing regarding the health of my patient, name: MOHAMED YAHYA RASHEED AL JUMA, Passport NO: VP3153200 (OMAN), D.O.B: 01/07/1991 The above-mentioned patient was born on the 1st day of July 1991 in Oman and a student at the KDU University in Malaysia. The student is set to go back for hi...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: Uncategorized Source Type: blogs
AbstractPurposeHashimoto ’s thyroiditis (HT) is often associated with rheumatic disorders (arthritis, etc.), but many HT patients report non-specific rheumatic signs and symptoms in the absence of clinically evident rheumatic diseases. Aim of this study was to evaluate the prevalence of non-specific rheumatic manifestatio ns (RMs) in HT subjects without classified autoimmune comorbidities.Methods500 HT patients (467 F, 33  M; median age 41 years, range 14–69) and 310 age- and sex-matched controls, consecutively referred to the Endocrine Unit of Messina University Hospital, were evaluated for non-speci...
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research
Abstract Juvenile fibromyalgia (JFM) is a chronic pain syndrome with onset in developmental age, characterized by widespread musculoskeletal pain associated with other neurological or nonneurological symptoms. Headache is one of the most frequent comorbid conditions with JFM, but this association is still poorly studied in the juvenile population. The literature review was conducted searching through PubMed, Scopus, and Web of Science with a combination of the following free-text terms: "fibromyalgia," "juvenile fibromyalgia," "headache," "primary headache," "migraine,&...
Source: Pain Research and Management - Category: Anesthesiology Authors: Tags: Pain Res Manag Source Type: research
Conclusion: While both mirogabalin doses were well tolerated by most patients and showed potential for reducing pain associated with FM, the primary endpoint of significant pain reduction in patients on mirogabalin compared with placebo was not achieved in any of the three randomized controlled studies. Clinical trial registration: NCT02146430; NCT02187159; NCT02187471; and NCT02234583 (extension study). PMID: 31284771 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
Source: Journal of Pain Research - Category: Anesthesiology Tags: Journal of Pain Research Source Type: research
Patients with fibromyalgia appear to have microbiome alterations, including deletions and an abundance of specific gut bacteria that differ from healthy controls.Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news
Evidence is growing demonstrating that intolerance to lactose is really just yet another manifestation of SIBO, small intestinal bacterial overgrowth. In a small Australian study, for instance, of 10 elderly people with lactose intolerance, 90% had SIBO (by lactulose H2 breath testing); eradication of SIBO reversed lactose intolerance in all initially SIBO-positive participants. Likewise, in an Italian study, lactose intolerance was associated with SIBO; eradication of SIBO resulted in most people being freed from lactose (as well as fructose and sorbitol) intolerance. It is part of the disruption of the digestive process ...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: SIBO a2 dairy grain-free lactose wheat belly Source Type: blogs
Authors: Ablin JN PMID: 31280518 [PubMed - in process]
Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research
This article presents the case of a 46-year-old woman with fibromyalgia with an undetected fracture of the coccyx. The heterogeneity of the symptoms of patients suffering from fibromyalgia including chronic widespread pain, vegetative and functional disorders, mental and physical exhaustion as well as sleep disorders can cause accidentally undetected comorbidities, especially if these are rare and predominantly present with pain as the main symptom. In the present case the reason for symptoms was detected only after 14 months of ineffective therapies and diagnostic procedures. The coccygeal pain was eliminat...
Source: Schmerz - Category: Anesthesiology Authors: Tags: Schmerz Source Type: research
This study examined the antinociceptive and antidepressant-like effects of imidazoline I2 receptor (I2R) agonists in a reserpine-induced model of fibromyalgia in rats. Rats were treated for 3 days with vehicle or reserpine. The von Frey filament test was used to assess the antinociceptive effects of I2 receptor agonists, and the forced swim test was used to assess the antidepressant-like effects of these drugs. 2-BFI (3.2–10 mg/kg, intraperitoneally), phenyzoline (17.8–56 mg/kg, intraperitoneally), and CR4056 (3.2–10 mg/kg, intraperitoneally) all dose-dependently produced significant ...
Source: Behavioural Pharmacology - Category: Drugs & Pharmacology Tags: RESEARCH REPORTS Source Type: research
More News: Fibromyalgia | Pharmaceuticals