Awaiting transplant, mom lives 6 days without lungs

Given the choice between his wife possibly dying in her bed or on an operating table, Chris Benoit chose an experimental, first-of-its-kind surgical procedure. The surgeons would remove not just one but both of Melissa Benoit's lungs.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news

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Heart transplantation is the definitive treatment for end-stage heart failure. A shortage of donor hearts forced transplant programs to accept older donors and longer ischemic times. Previous studies have suggested that the administration of mesenchymal stem cells (MSCs) or their conditioned medium (CM) protects the heart against ischemia/reperfusion injury (IRI). We hypothesized that the preservation of donor hearts with a CM would protect the graft from IRI after prolonged storage in 15-month-old rats and investigated mRNA-changes attributable to CM.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Pre-Clinical Science Source Type: research
Chronic lung allograft dysfunction (CLAD) affects over 50% of lung transplant recipients (LTR) by five years and remains the primary reason for graft failure 1. It has been increasingly recognized that CLAD is a heterogeneous diagnosis with variable prognosis and different phenotypes: bronchiolitis obliterans syndrome (BOS) and restrictive allograft syndrome (RAS). Precise diagnosis of CLAD remains difficult: There are no clinically-validated biomarkers, and diagnosis can be subjective, hinging on the correct interpretation of pulmonary function tests (PFTs) coupled with exclusion of clinical confounders.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: RESEARCH CORRESPONDENCE Source Type: research
The added value of cardiopulmonary exercise testing (CPET) in the follow-up of patients with stable pulmonary arterial hypertension (PAH) remains undefined.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Clinical Science Source Type: research
Chronic lung allograft dysfunction (CLAD) is a major cause of post-lung transplant mortality with limited medical treatment options. We assessed the association of montelukast treatment with pulmonary function and outcome in lung transplant recipients with progressive CLAD.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Right ventricular failure (RVF) is still associated with an increased mortality in patients with pulmonary hypertension (PH) or congenital heart disease. Transition from right ventricular dysfunction to RVF is not predictable and has not been well understood so far. Several studies in rodents and in piglets showed that impairment of capillary density (CD) in the right ventricle (RV) is associated with right ventricular failure (1, 2). Some evidence suggested that the RV of patients with Eisenmenger Syndrome (ES) has remarkable adaptive capacities to high pulmonary pressures (3), leading to a longer survival in these patien...
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Research Correspondence Source Type: research
Journal of Cardiac Surgery, EarlyView.
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: IMAGES IN CARDIAC SURGERY Source Type: research
The outcome of second solid cancers following hematopoietic stem cell transplantation (HSCT) is strongly related to cancer type, with pancreatic and lung cancer being among those with the poorest outcome, according to European researchers.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Medscape Today News Source Type: news
Authors: Mortaz E, Amani S, Mumby S, Adcock IM, Movassaghi M, Folkerts J, Garssen J, Folkerts G Abstract The multifunctional role of mast cells (MCs) in the immune system is complex and has not fully been explored. MCs reside in tissues and mucous membranes such as the lung, digestive tract, and skin which are strategically located at interfaces with the external environment. These cells, therefore, will encounter external stimuli and pathogens. MCs modulate both the innate and the adaptive immune response in inflammatory disorders including transplantation. MCs can have pro- and anti-inflammatory functions, thereb...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
Conclusion: Our findings indicate that GAPLINC promotes NSCLC tumorigenesis by regulating miR-661/eEF2K cascade and provide new insights for the pathogenesis underlying NSCLC and potential targets for therapeutic strategy.Cell Physiol Biochem 2018;51:2136 –2147
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
Condition:   Lung Transplant; Complications Intervention:   Other: Colection of clinical data Sponsors:   Hospital Universitari Vall d'Hebron Research Institute;   Instituto de Salud Carlos III Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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