The clinical and neurobehavioral course of Down syndrome and dementia with or without new-onset epilepsy.

DISCUSSION: New-onset epilepsy seems to occur early in the course of dementia in DS patients. Patients generally respond to treatment. A great burden of neuropsychiatric symptoms is seen. Future studies need to explore the relationship between β-amyloid accumulation and epileptiform activity and attend to the care and needs of DS patients with dementia and seizures. PMID: 28109983 [PubMed - as supplied by publisher]
Source: Epilepsy and Behaviour - Category: Neurology Authors: Tags: Epilepsy Behav Source Type: research

Related Links:

Publication date: Available online 20 January 2020Source: Biochimica et Biophysica Acta (BBA) - BiomembranesAuthor(s): Li Kong, Edgar Dawkins, Frederick Campbell, Edith Winkler, Rico J.E. Derks, Martin Giera, Frits Kamp, Harald Steiner, Alexander KrosAbstractThe biophysical properties and biological functions of membranes are highly dependent on lipid composition. Supplementing cellular membranes with very long chain fatty acids (vlcFAs) is notoriously difficult given the extreme insolubility of vlcFAs in aqueous solution. Herein, we report a solvent-free, photochemical approach to enrich target membranes with vlcFA. To pr...
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - Category: Biochemistry Source Type: research
Our study aimed at the development of a method based on ultra-performance liquid chromatography coupled to mass spectrometry (UPLC-ESI-MS) using selected ion monitoring for the simultaneous quantitation of the alkaloids galantamine, pseudolycorine, sanguinine and narciclasine in Amaryllidaceae species (Hippeastrum elegans, Habranthus cf. irwinianus, Hymenocallis littoralis and Griffinia nocturna). The alkaloids were extracted from dried and ground bulbs (100 mg) using liquid-liquid microextraction followed by solid phase extraction in cation exchange cartridges. The quantification method showed good linearity (correlation ...
Source: Journal of the Brazilian Chemical Society - Category: Chemistry Source Type: research
Wearable technology allows an in-depth analysis of gait behaviour in free-living environments. This investigation aimed to use Alzheimer's disease as an example to apply the time series analysis technique of Statistical Parametric Mapping (SPM) to create d...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
We examined the changes in physical function after feet and toenails care for frail elderly adults and elderly adults with dementia. As a result, the abnormalit...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
People Living with Dementia (PLwD) often exhibit behavioral and psychological symptoms of dementia; with agitation being one of the most prevalent symptoms. Agitated behaviour in PLwD indicates distress and confusion and increases the risk to injury to bot...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
In the Editorial titled “Prevalence and Severity of Alzheimer Disease in Individuals With Down Syndrome,” published online November 19, 2018, a typographical error was corrected in the sentence in the third paragraph that includes the phrase “late-onset epilepsy increased mortality risk in individuals with DS and dem entia by 10-fold.” The phrase “in individuals with DS and dementia” was changed to “in individuals with DS without dementia.”
Source: JAMA Neurology - Category: Neurology Source Type: research
Discussion New-onset epilepsy seems to occur early in the course of dementia in DS patients. Patients generally respond to treatment. A great burden of neuropsychiatric symptoms is seen. Future studies need to explore the relationship between β-amyloid accumulation and epileptiform activity and attend to the care and needs of DS patients with dementia and seizures.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Purpose of review: Alzheimer's disease is most likely universal in older individuals with Down syndrome, due to having three copies of the amyloid precursor protein gene, resulting in amyloid-beta plaque deposition. Down syndrome is an important population in which to consider clinical trials of treatments to prevent or delay the development of dementia. However, assessment of subtler cognitive changes is challenging due to the presence of intellectual disability. Recent findings: Recent research confirmed that older adults with Down syndrome often present with cognitive decline: more than 80% may experience dementia by a...
Source: Current Opinion in Psychiatry - Category: Psychiatry Tags: NEURODEVELOPMENTAL DISORDERS: Edited by James C. Harris Source Type: research
Abstract PURPOSE OF REVIEW: Alzheimer's disease is most likely universal in older individuals with Down syndrome, due to having three copies of the amyloid precursor protein gene, resulting in amyloid-beta plaque deposition. Down syndrome is an important population in which to consider clinical trials of treatments to prevent or delay the development of dementia. However, assessment of subtler cognitive changes is challenging due to the presence of intellectual disability. RECENT FINDINGS: Recent research confirmed that older adults with Down syndrome often present with cognitive decline: more than 80% may ex...
Source: Epilepsy Curr - Category: Neurology Authors: Tags: Curr Opin Psychiatry Source Type: research
CONCLUSIONS: New onset epilepsy seems to occur early in the course of dementia in DS patients. It is unclear if epilepsy has a role in dementia progression. Treatment response was generally good except for epileptic myoclonus. Future studies are needed to study patients with DS and dementia, with and without epilepsy and investigate the interplay between Alzheimer’s dementia pathology.Disclosure: Dr. Gholipour has nothing to disclose. Dr. Sarkis has nothing to disclose. Dr. El-Chemali has nothing to disclose.
Source: Neurology - Category: Neurology Authors: Tags: Epilepsy/Clinical Neurophysiology (EEG): Clinical Epilepsy Source Type: research
More News: Alzheimer's | Dementia | Down's Syndrome | Epilepsy | Neurology | Psychiatry | Study