Tweak up-regulates endothelin-1 system in mouse and human endothelial cells

Conclusions In pathological situations such as chronic inflammation, TWEAK could be more harmful through this effect at endothelial level. Pharmacological blockade of this cytokine could prevent the haemodynamic and structural changes related to an increased ET-1 synthesis.
Source: Cardiovascular Research - Category: Cardiology Authors: Tags: Vascular biology Source Type: research

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A large meta-analysis finds that reducing sodium levels in our food lowers blood pressure in all of us, even those without hypertension, which could be a way to fight the number one killer: heart disease.
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Hormones are largely responsible for the integrated communication of several physiological systems responsible for modulating cellular growth and development. Although the specific hormonal influence must be considered within the context of the entire endocrine system and its relationship with other physiological systems, three key hormones are considered the “anabolic giants” in cellular growth and repair: testosterone, the growth hormone superfamily, and the insulin-like growth factor (IGF) superfamily. In addition to these anabolic hormones, glucocorticoids, mainly cortisol must also be considered because of...
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