Attenuation of carotid neointimal formation after direct delivery of a recombinant adenovirus expressing glucagon-like peptide-1 in diabetic rats
Conclusion
Direct GLP-1 overexpression showed better protection against restenosis after balloon injury via suppression of vascular smooth muscle cell migration, increased apoptosis, and decreased inflammatory processes than systemic exenatide treatment. This has potential therapeutic implications for treating macrovascular complications in diabetes.
Source: Cardiovascular Research - Category: Cardiology Authors: Lim, S., Lee, G. Y., Park, H. S., Lee, D.-H., Tae Jung, O., Kyoung Min, K., Kim, Y.-B., Jun, H.-S., Hak Chul, J., Park, K. S. Tags: Vascular biology Source Type: research
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