Sphingosine-1-phosphate signalling--a key player in the pathogenesis of Angiotensin II-induced hypertension

Conclusion The presented results point to a critical involvement of S1P and its signalling axis in the pathogenesis of hypertension. Specifically, SphK2 evolves as key player in immune cell trafficking and vascular dysfunction contributing to the development of overt hypertension.

http://cardiovascres.oxfordjournals.org/cgi/content/short/113/2/123?rss=1

Source: Cardiovascular Research - January 22, 2017 Category: Cardiology Authors: Meissner, A., Miro, F., Jimenez-Altayo, F., Jurado, A., Vila, E., Planas, A. M. Tags: Integrative physiology and pathophysiology Source Type: research