SRF/myocardin: a novel molecular axis regulating vascular smooth muscle cell stiffening in hypertension

Source: Cardiovascular Research - Category: Cardiology Authors: Tags: Invited Editorials Source Type: research

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CrystEngComm, 2020, Accepted Manuscript DOI: 10.1039/C9CE01818B, PaperJamshed Haneef, Renu Chadha The present work focused on the development of pharmaceutical cocrystal of ambrisentan (AMT) with low aqueous solubility used to treat pulmonary arterial hypertension. In this regard, a novel cocrystal of... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - CrystEngComm latest articles - Category: Chemistry Authors: Source Type: research
Authors: Denis Le Seve J, Gourraud Vercel C, Connault J, Artifoni M Abstract Cholesterol crystal embolism is a systemic pathology associated with diffuse atherosclerosis. Pathophysiology corresponds to tissue necro-inflammation secondary to arteriolar occlusion associated with microembolism from atherosclerotic plaques of large diameter arteries. The clinical presentation is heterogeneous and polymorphic. Multiple organs may be the targets, but preferential damage is skin, kidneys and digestive system. It is a serious pathology, underdiagnosed, with a poor prognosis. The risk factors for developing the disease rema...
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research
Authors: Aubry A, Paternot A, Vieillard-Baron A Abstract Cor pulmonale is a disease of the heart characterised by dilatation of the right ventricle and paradoxical movement of the interventricular septum. The diagnosis depends on echocardiography even if pulmonary artery catheterisation suggests it. It is secondary to pulmonary disease or a disorder of the pulmonary circulation. These two mechanisms, which are often connected, involve pulmonary hypertension as the origin of a systolic and diastolic overload of the right ventricle, which then leads to the alterations of its structure and performance. Acute cor pulmo...
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
Conditions:   Hypertension;   Cardiac Disease Interventions:   Procedure: combined exercise;   Procedure: aerobic exercise Sponsor:   IRCCS San Raffaele Recruiting
Source: - Category: Research Source Type: clinical trials
Conditions:   Pulmonary Arterial Hypertension;   Pulmonary Arterial Remodeling Intervention:   Sponsor:   University of Campania  " Luigi  Vanvitelli " Recruiting
Source: - Category: Research Source Type: clinical trials
TRENTON, N.J. (AP) — U.S. regulators on Friday approved a new type of cholesterol-lowering drug aimed at millions of people who can’t tolerate — or don’t get enough help from — widely used statin pills like Lipitor and Crestor. The Food and Drug Administration approved Esperion Therapeutics Inc.’s Nexletol for people genetically predisposed to have sky-high cholesterol and people who have heart disease and need to further lower their bad cholesterol. The daily pill is to be taken in conjunction with a healthy diet and the highest statin dose patients can handle, the FDA said. High LDL, o...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News Syndicated CBSN Boston Cholesterol Statins Source Type: news
HIGH BLOOD pressure is medically known as hypertension and having the condition puts a person at risk of having a heart attack or stroke. There is a lesser known condition known as secondary hypertension, which can also result in some life-threatening complications. What is it and what are the symptoms?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Authors: Liegeon G, Antoni G, Pialoux G, Capitant C, Cotte L, Charreau I, Tremblay C, Cua E, Senneville E, Raffi F, Meyer L, Molina JM, ANRS-IPERGAY study group Abstract INTRODUCTION: Daily pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) is associated with a small but statistically significant decrease in estimated glomerular filtration rate (eGFR). We assessed the renal safety of on-demand PrEP with TDF/FTC in HIV-1 uninfected men. METHODS: We used data from the randomized double-blind placebo-controlled ANRS-IPERGAY trial and its open-label extension conducted betwee...
Source: Journal of the International AIDS Society - Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research
This population-based cohort study evaluates the association between being newly dispensed a calcium channel blocker and subsequent dispensing of a loop diuretic in older adults with hypertension.
Source: JAMA Internal Medicine - Category: Internal Medicine Source Type: research
ConclusionsThe study shows that primary care doctors demonstrated adequate knowledge about OSA and were aware of the importance of OSA as a core clinical problem. However, only a minority felt confident in managing patients with OSA. The results of the study may encourage improvement of primary care doctors ’ efforts to prevent and manage OSA.
Source: Sleep and Breathing - Category: Respiratory Medicine Source Type: research
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