Amino acid based material for the complementary therapy of Decubitus Ulcers.

Amino acid based material for the complementary therapy of Decubitus Ulcers. J Microbiol Biotechnol. 2017 Jan 20;: Authors: Nogueira F, Gouveia IC Abstract Chronic wounds, pressure sores, lesions and infections of microbial origin in bedridden, paralyzed or malnutrition patients remain the object of study of many researchers. There are several intrinsic and extrinsic factors involved in the development of these disorders, which are related to the patient's immune system, making it unable to respond effectively to the treatment of the wound. These factors can be properly controlled, giving particular importance to the ethiology and stage of the wound, as well as the time periods corresponding to the replacement of the dressings. The present research reports a novel foam/soft material L-Cys-g-PCL with an application for decubitus/pressure ulcers, especially for wounds with a difficult healing process due to infections and constant oxidation of the soft tissues. During this work, the interactions between S. aureus and L-Cys-g-PCL foam were studied under conditions that simulate decubitus ulcers, namely pH and exudate. The effect of duration of grafting (1 or 8 hours), and pH (7.0 and 8.9) on wettability, surface energy, swelling, and porosity, was also evaluated. Results showed an effective microbicidal activity exhibiting inhibition ratios of 99.73% against S. aureus. This new L-Cys-g-PCL soft material showed saftey to contact skin, ab...
Source: Journal of Microbiology and Biotechnology - Category: Biotechnology Authors: Tags: J Microbiol Biotechnol Source Type: research