Music Training May Facilitate Memory Function in Alzheimer ’s Disease

Alzheimer’s disease (AD) has long been considered a detrimental form of dementia. With over 35 million individuals globally living with dementia and this number predicted to triple in the next thirty years (World Health Organization, 2012); it is now vital that effective pharmacological treatments help modify the disease and improve individual’s quality of life — as current pharmacological treatments have only been effective in relation to relieving the severity of symptoms. As a result researchers have looked to investigate whether other non-pharmacological treatments can supplement pharmacological treatments to aid AD sufferers in their battle with the disease. There is growing amounts of evidence demonstrating that music interventions are effective in treating dementia such as relieving symptoms and eliciting positive physiological effects — whether it be listening, music therapy or musical activities. Impaired memory is the most common symptom of AD individuals and most research has focused on the effect visual and verbal stimuli has on AD. However researchers such as Cuddy have investigated the possibility of memory for music which may be accessed differently than visual and verbal stimuli. For example there are cases of musicians with AD continuing to play their instrument and learning new pieces of music despite their impaired memory due to their disease (Cowles et al, 2003). This is backed up by evidence that suggests lyrics in a song aid verb...
Source: Psych Central - Category: Psychiatry Authors: Tags: Aging Alzheimer's Caregivers Disabilities Memory and Perception Alzheimer's disease Cognition Dementia Music Therapy Source Type: news

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CONCLUSION: Vascular disease, inflammation and impaired brain insulin signaling might occur in T2D and contribute to dementia risk. Evidence from epidemiological studies has not consistently reported associations that could integrate a unified mechanism of disease in humans. Evaluation of the effect of antidiabetic medications and non-pharmacological interventions in dementia prevention in type 2 diabetes is promising but has thus far offered inconsistent results. PMID: 30648514 [PubMed - as supplied by publisher]
Source: Current Diabetes Reviews - Category: Endocrinology Authors: Tags: Curr Diabetes Rev Source Type: research
Abstract In the context of neurodegeneration and aging, the cerebellum is an enigma. Genetic markers of cellular aging in cerebellum accumulate more slowly than in the rest of the brain, and it generates unknown factors that may slow or even reverse neurodegenerative pathology in animal models of Alzheimer's Disease (AD). Cerebellum shows increased activity in early AD and Parkinson's disease (PD), suggesting a compensatory function that may mitigate early symptoms of neurodegenerative pathophysiology. Perhaps most notably, different parts of the brain accumulate neuropathological markers of AD in a recognized pro...
Source: Neurobiology of Learning and Memory - Category: Neurology Authors: Tags: Neurobiol Learn Mem Source Type: research
In conclusion, we found a gradient of increasing blood pressure with higher levels of BMI. The fact that this gradient is present even in the fully adjusted analyses suggests that BMI may cause a direct effect on blood pressure, independent of other clinical risk factors. PRRX1 as a Possible Point of Control for Remyelination https://www.fightaging.org/archives/2018/12/prrx1-as-a-possible-point-of-control-for-remyelination/ Researchers here outline what is possibly a new point of intervention in the processes that maintain the myelin sheath that wraps nerves. This sheath is vital to the correct operatio...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Abstract Alzheimer's disease (AD) is the sixth leading cause of death globally and the main reason for dementia in elderly people. AD is a long-term and progressive neurodegenerative disorder that steadily worsens memory and communicating skills eventually leads to a disabled person of performing simple daily tasks. Unfortunately, numerous clinical trials exploring new therapeutic drugs have encountered disappointing outcomes in terms of improved cognitive performance since they are not capable of halting or stimulating the regeneration of already-damaged neural cells, and merely provide symptomatic relief. Theref...
Source: Molecular Biology Reports - Category: Molecular Biology Authors: Tags: Mol Biol Rep Source Type: research
AbstractNicotinamide adenine dinucleotide (NAD) supplementation to repair the disabled mitochondria is a promising strategy for the treatment of Alzheimer ’s disease (AD) and other dementia. Nicotinamide ribose (NR) is a safe NAD precursor with high oral bioavailability, and has beneficial effects on aging. Here, we applied NR supplied food (2.5 g/kg food) to APP/PS1 transgenic AD model mice and aged mice for 3 months. Cognitive function, locomoto r activity and anxiety level were assessed by standard behavioral tests. The change of body weight, the activation of microglia and astrocytes, the accumulation o...
Source: Metabolic Brain Disease - Category: Neurology Source Type: research
DiscussionDietary changes initiated during the intervention were related to changes in executive function in 2 years. Long-term diet appeared more influential for global cognition.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Abstract INTRODUCTION: Alzheimer's pathology is a neurodegenerative disease characterized by cognitive impairment and functional disability that causesprogressive restrictions in daily activities. The present study associates nutritional status with cognitive and clinical aspects of the elderly withmild, moderate and severe Alzheimer's disease (AD). METHODS: data from the Mini Nutritional Assessment (MNA), bioelectrical impedance (BIA), anthropometric measurements, and physical activityindicators were associated with clinical and cognitive aspects of 43 elderly patients with AD. The data were compared to a pa...
Source: Nutricion Hospitalaria - Category: Nutrition Authors: Tags: Nutr Hosp Source Type: research
This article, however, is more of a commentary on high level strategy and the effects of regulation, coupled with a desire to forge ahead rather than hold back in the matter of treating aging, thus I concur with much more of what is said than is usually the case. For decades, one of the most debated questions in gerontology was whether aging is a disease or the norm. At present, excellent reasoning suggests aging should be defined as a disease - indeed, aging has been referred to as "normal disease." Aging is the sum of all age-related diseases and this sum is the best biomarker of aging. Aging and its d...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: Available online 26 November 2018Source: The Lancet NeurologyAuthor(s): Emma Nichols, Cassandra E I Szoeke, Stein Emil Vollset, Nooshin Abbasi, Foad Abd-Allah, Jemal Abdela, Miloud Taki Eddine Aichour, Rufus O Akinyemi, Fares Alahdab, Solomon W Asgedom, Ashish Awasthi, Suzanne L Barker-Collo, Bernhard T Baune, Yannick Béjot, Abate B Belachew, Derrick A. Bennett, Belete Biadgo, Ali Bijani, Muhammad Shahdaat Bin Sayeed, Carol BrayneSummaryBackgroundThe number of individuals living with dementia is increasing, negatively affecting families, communities, and health-care systems around the world. A succ...
Source: The Lancet Neurology - Category: Neurology Source Type: research
This study is the culmination of a decade of research that has repeatedly demonstrated that this vaccine can effectively and safely target in animal models what we think may cause Alzheimer's disease. I believe we're getting close to testing this therapy in people." Although earlier research established that antibodies significantly reduce amyloid buildup in the brain, researchers needed to find a safe way to introduce them into the body. A vaccine developed elsewhere showed promise in the early 2000s, but when tested in humans, it caused brain swelling in some patients. The new idea was to start with DNA codin...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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