Congenital adrenal hyperplasia
Congenital adrenal hyperplasia is a genetic condition affecting the adrenal glands and interfering with normal growth and development in boys and girls.
Liza Das, Nimisha Jain, Anshita Aggarwal, Pinaki Dutta, Anil BhansaliNeurology India 2020 68(3):688-690
ccedil; N, Kandemir N Abstract BACKGROUND AND OBJECTIVES: Congenital adrenal hyperplasia (CAH) is characterized by androgen excess which should be treated with life-long glucocorticoid therapy, thus can affect bone mineralization. We aimed to evaluate the bone mineral density (BMD) and determine the factors affecting bone mineralization in patients with CAH. METHOD: This prospective case-control study was conducted in children, adolescents and young adults with classical 21-hydroxylase CAH, and age-, sex-, and pubertal stage matched healthy controls. Lumbar1-4 BMD was determined by dual-energy X-ray absorptio...
Congenital Adrenal Hyperplasia (CAH) is the commonest cause of disorders of sex development (DSD) in children. The timing of surgery, early versus late, is a subject of current debate. We hypothesize that surgery for congenital adrenal hyperplasia after age two results in a worse outcome than procedures performed earlier in the neonatal period."
AbstractPurposeWe compared the sexual function in women with classic forms of congenital adrenal hyperplasia (CAH) and polycystic ovary syndrome (PCOS) to find if the cause of androgen excess determines sexual functioning.MethodsHundred and four women (21 with CAH, 63 with PCOS and 20 healthy controls) aged 18 –40 years were included into the study. All participants completed a questionnaire regarding their sociodemographic background and underwent anthropometric and basic biochemical measurements. Plasma levels of total testosterone, androstenedione, and 17-hydroxyprogesterone were measured with immun oassay. T...
Congenital Adrenal Hyperplasia (CAH) is the most common reason for undifferentiated genital appearance in new-borns. Psychosexual outcome in women with CAH has been rarely evaluated, but it seems to be one of the most important factors determining the indications for the surgical treatment of CAH.
Conclusions: Early feminizing genitoplasty in girls with congenital adrenal hyperplasia, irrespective of virilization severity, gives satisfactory cosmetic results and is characterized by low and acceptable surgical risk. Nevertheless, the most important determinant of the effectiveness of such management would be future patients’ satisfaction.
To explore how women with congenital adrenal hyperplasia (CAH) describe their experiences of gender role behavior, psychosexual development and intimate relationships. CAH results in increased androgen exposure in affected females and is the most common reason for unclear sex at birth. Women with CAH have been studied to find answers to the role of androgens in psychosexual development. Nevertheless, factors that may account for the variability of outcomes in women with CAH are unclear.
Publication date: Available online 17 May 2020Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Leif Karlsson, Michela Barbaro, Ewoud Ewing, David Gomez-Cabrero, Svetlana Lajic
Conclusion: ACAT1 inhibitors [11C]ATR-101 and [18F]ATR-F were synthesized. Biodistribution studies showed good adrenal uptake for both agents. [11C]ATR-101 when administered to (healthy) C57BL6 and (atherosclerotic) ApoE-/- mice could easily distinguish the diseased animal from the healthy control. Future studies will use PET/CT for additional structural information, and [18F]ATR-F will be used in longer imaging studies. References: (1) Yu, X.-H.; Fu, Y.-C.; Zhang, D.-W.; Yin, K.; Tang, C.-K. Foam Cells in Atherosclerosis. Clin. Chim. Acta 2013, 424, 245-252.(2) Trivedi, B. K.; Purchase, T. S.; Holmes, A.; Augelli-szafran,...
CONCLUSIONS: Our report suggests the need for screening of liver lesions in males affected by this syndrome. PMID: 32373953 [PubMed - in process]